Varaico: Literature-Extracted Genetic Variants

Gene:TBXT
Variant:p.G177D
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TBXT

NM_001366285.2:p.G177D

Associated Papers

Thoracic chordoma following intracranial meningioma in a patient with a novel germline SMARCE1 variant.

Tsurubuchi T et al.

European Journal of Medical Genetics, 2026

Selective targeting of TBXT with DARPins identifies regulatory networks and therapeutic vulnerabilities in chordoma.

Umbaugh CS et al.

Science Advances, 2025

The TBXT rs2305089 SNP links the benign notochordal cell tumour and chordoma.

Usher I et al.

The Journal of Pathology, 2025

Structural insights into human brachyury DNA recognition and discovery of progressible binders for cancer therapy.

Newman JA et al.

Nature Communications, 2025

The pharmacogenomic landscape in the Chinese: An analytics of pharmacogenetic variants in 206,640 individuals.

Wang LY et al.

Innovation (cambridge (mass.)), 2025

39991480 (PubMed )
Supplement: mmc5.xlsx › Sheet1

The mutational landscape of skull base and spinal chordomas and the identification of potential prognostic and theranostic biomarkers.

Passeri T et al.

Journal of Neurosurgery, 2023

Association between TBXT rs2305089 polymorphism and chordoma in Iranian patients identified by a developed T-ARMS-PCR assay.

Jalessi M et al.

Journal of Clinical Laboratory Analysis, 2022

Multiple malignant tumors in a patient with familial chordoma, a case report.

Sumransub N et al.

Bmc Medical Genomics, 2021

Inhibition of Histone H3K27 Demethylases Inactivates Brachyury (TBXT) and Promotes Chordoma Cell Death.

Cottone L et al.

Cancer Research, 2020

Small-molecule targeting of brachyury transcription factor addiction in chordoma.

Sharifnia T et al.

Nature Medicine, 2019

Establishment and genomic characterization of the new chordoma cell line Chor-IN-1.

Bosotti R et al.

Scientific Reports, 2017

The brachyury Gly177Asp SNP is not associated with a risk of skull base chordoma in the Chinese population.

Wu Z et al.

International Journal of Molecular Sciences, 2013

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."