Associated Papers
Dysregulated human Tyrosyl-DNA phosphodiesterase I acts as cellular toxin.
Cuya SM et al.
Oncotarget, 2016
Analysis of the active-site mechanism of tyrosyl-DNA phosphodiesterase I: a member of the phospholipase D superfamily.
Gajewski S et al.
Journal of Molecular Biology, 2012
In vitro complementation of Tdp1 deficiency indicates a stabilized enzyme-DNA adduct from tyrosyl but not glycolate lesions as a consequence of the SCAN1 mutation.
Hawkins AJ et al.
Dna Repair, 2009
SCAN1 mutant Tdp1 accumulates the enzyme--DNA intermediate and causes camptothecin hypersensitivity.
Interthal H et al.
The Embo Journal, 2005
Mutation of TDP1, encoding a topoisomerase I-dependent DNA damage repair enzyme, in spinocerebellar ataxia with axonal neuropathy.
Takashima H et al.
Nature Genetics, 2002
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