Associated Papers
Venous Malformations: Unraveling Latest Mechanisms and Bridging Gaps in Targeted Therapy Development.
Jiang X et al.
International Journal of Biological Sciences, 2025
Strain-release alkylation of Asp12 enables mutant selective targeting of K-Ras-G12D.
Zheng Q et al.
Nature Chemical Biology, 2024
Obscurin Rho GEF domains are phosphorylated by MST-family kinases but do not exhibit nucleotide exchange factor activity towards Rho GTPases in vitro.
Koch D et al.
Plos One, 2023
Systematic analysis of the intersection of disease mutations with protein modifications.
Simpson CM et al.
Bmc Medical Genomics, 2019
The Pathogenesis of Port Wine Stain and Sturge Weber Syndrome: Complex Interactions between Genetic Alterations and Aberrant MAPK and PI3K Activation.
Nguyen V et al.
International Journal of Molecular Sciences, 2019
Review of the endothelial pathogenic mechanism of TIE2-related venous malformation.
Du Z et al.
Journal of Vascular Surgery. Venous and Lymphatic Disorders, 2017
A selective chemical probe for exploring the role of CDK8 and CDK19 in human disease.
Dale T et al.
Nature Chemical Biology, 2015
Common and specific effects of TIE2 mutations causing venous malformations.
Nätynki M et al.
Human Molecular Genetics, 2015
PhosphoSitePlus, 2014: mutations, PTMs and recalibrations.
Hornbeck PV et al.
Nucleic Acids Research, 2015
[Haplotype analysis for mucocutaneous venous malformations in a Chinese Han ethnic family].
Shu W et al.
Yi Chuan = Hereditas, 2012
Hereditary cutaneomucosal venous malformations are caused by TIE2 mutations with widely variable hyper-phosphorylating effects.
Wouters V et al.
European Journal of Human Genetics : Ejhg, 2010
Genome-wide analysis to predict protein sequence variations that change phosphorylation sites or their corresponding kinases.
Ryu GM et al.
Nucleic Acids Research, 2009
Somatic mutations in angiopoietin receptor gene TEK cause solitary and multiple sporadic venous malformations.
Limaye N et al.
Nature Genetics, 2009
Genetic causes of vascular malformations.
Brouillard P et al.
Human Molecular Genetics, 2007
Vascular malformations: localized defects in vascular morphogenesis.
Brouillard P et al.
Clinical Genetics, 2003
Structure of the Tie2 RTK domain: self-inhibition by the nucleotide binding loop, activation loop, and C-terminal tail.
Shewchuk LM et al.
Structure (london, England : 1993), 2000
Allelic and locus heterogeneity in inherited venous malformations.
Calvert JT et al.
Human Molecular Genetics, 1999
Vascular anomalies of the head and neck: a review of genetics.
Yadav P et al.
Seminars in Ophthalmology, 0