Associated Papers
Human RPA is an essential telomerase processivity factor for maintaining telomeres.
Agrawal S et al.
Science (new York, N.y.), 2025
Cryo-EM structure of human telomerase dimer reveals H/ACA RNP-mediated dimerization.
Balch S et al.
Science (new York, N.y.), 2025
Novel telomerase reverse transcriptase gene mutation in a family with aplastic anaemia.
Virijevic M et al.
Familial Cancer, 2024
Telomerase Reverse Transcriptase Preserves Neuron Survival and Cognition in Alzheimer's Disease Models.
Shim HS et al.
Nature Aging, 2021
Telomerase therapy reverses vascular senescence and extends lifespan in progeria mice.
Mojiri A et al.
European Heart Journal, 2021
Telomerase promotes formation of a telomere protective complex in cancer cells.
Perera ON et al.
Science Advances, 2019
Transient introduction of human telomerase mRNA improves hallmarks of progeria cells.
Li Y et al.
Aging Cell, 2019
Structural, functional, and stability change predictions in human telomerase upon specific point mutations.
Kalathiya U et al.
Scientific Reports, 2019
Human telomerase protein: Understanding how the catalytic activity is suppressed under single substitutions of some conserved residues. A computational study.
Herrera FE et al.
Proteins, 2018
Many disease-associated variants of hTERT retain high telomerase enzymatic activity.
Zaug AJ et al.
Nucleic Acids Research, 2013
Human telomerase catalytic subunit (hTERT) suppresses p53-mediated anti-apoptotic response via induction of basic fibroblast growth factor.
Jin X et al.
Experimental & Molecular Medicine, 2010
Mutations in the tetramerization domain of p53: more than just keeping monomers apart.
Goldstein I et al.
Cell Cycle (georgetown, Tex.), 2009
Two independent regions of human telomerase reverse transcriptase are important for its oligomerization and telomerase activity.
Arai K et al.
The Journal of Biological Chemistry, 2002
Reconstitution of human telomerase activity in vitro.
Beattie TL et al.
Current Biology : Cb, 1998
Telomerase activation by hTRT in human normal fibroblasts and hepatocellular carcinomas.
Nakayama J et al.
Nature Genetics, 1998
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