Varaico: Literature-Extracted Genetic Variants

Gene:TERT
Variant:p.G100V
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TERT

NM_198253.3:p.G100V

Associated Papers

Interaction hub critical for telomerase recruitment and primer-template handling for catalysis.

Padmanaban S et al.

Life Science Alliance, 2023

Identification of human TERT elements necessary for telomerase recruitment to telomeres.

Schmidt JC et al.

Elife, 2014

Genetic and molecular identification of three human TPP1 functions in telomerase action: recruitment, activation, and homeostasis set point regulation.

Sexton AN et al.

Genes & Development, 2014

Many disease-associated variants of hTERT retain high telomerase enzymatic activity.

Zaug AJ et al.

Nucleic Acids Research, 2013

Specificity requirements for human telomere protein interaction with telomerase holoenzyme.

Sexton AN et al.

The Journal of Biological Chemistry, 2012

TPP1 OB-fold domain controls telomere maintenance by recruiting telomerase to chromosome ends.

Zhong FL et al.

Cell, 2012

Functional interaction between telomere protein TPP1 and telomerase.

Zaug AJ et al.

Genes & Development, 2010

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."