Varaico: Literature-Extracted Genetic Variants

Gene:TET2
Variant:p.H1382Y
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TET2

NM_001127208.3:p.H1382Y

Associated Papers

Clonal hematopoiesis is associated with distinct rheumatoid arthritis phenotypes.

Hiitola E et al.

Science Advances, 2025

40305610 (PubMed )
Supplement: sciadv.adt9846_tables_s1_to_s13.zip › adt9846_tables_s1_to_s13.xlsx › S3

Neomorphic leukemia-derived mutations in the TET2 enzyme induce genome instability via a substrate shift from 5-methylcytosine to thymine.

Jin GB et al.

Proceedings of the National Academy of Sciences of the United States of America, 2025

39874291 (PubMed )
Supplement: pnas.2418318122.sapp.pdf

Risk prediction for clonal cytopenia: multicenter real-world evidence.

Xie Z et al.

Blood, 2024

38996210 (PubMed )
Supplement: BLOOD_BLD-2024-024756-mmc1.pdf

NSUN5/TET2-directed chromatin-associated RNA modification of 5-methylcytosine to 5-hydroxymethylcytosine governs glioma immune evasion.

Wu R et al.

Proceedings of the National Academy of Sciences of the United States of America, 2024

38547058 (PubMed )
Supplement: pnas.2321611121.sapp.pdf

Genomic characterization of thymic epithelial tumors reveals critical genes underlying tumorigenesis and poor prognosis.

Tan S et al.

Clinical Genetics, 2023

The Impact of Inflammation-Induced Tumor Plasticity during Myeloid Transformation.

Yeaton A et al.

Cancer Discovery, 2022

EPHA5 mutation was associated with adverse outcome of atezolizumab treatment in late-stage non-small cell lung cancers.

Li Z et al.

Bmc Pulmonary Medicine, 2022

36123678 (PubMed )
Supplement: 12890_2022_2161_MOESM2_ESM.xlsx › OAK_POPLAR_btmb_variants

TET2-BCLAF1 transcription repression complex epigenetically regulates the expression of colorectal cancer gene Ascl2 via methylation of its promoter.

Shang Y et al.

The Journal of Biological Chemistry, 2022

Correlation of mutational landscape and survival outcome of peripheral T-cell lymphomas.

Ye Y et al.

Experimental Hematology & Oncology, 2021

33546774 (PubMed )
Supplement: 40164_2021_200_MOESM2_ESM.xlsx › Table_S2

Histone modifier gene mutations in peripheral T-cell lymphoma not otherwise specified.

Ji MM et al.

Haematologica, 2018

29305415 (PubMed )
Supplement: 2017.182444.Ji_SUPPL.pdf

TET2-mediated 5-hydroxymethylcytosine induces genetic instability and mutagenesis.

Mahfoudhi E et al.

Dna Repair, 2016

Overlapping Requirements for Tet2 and Tet3 in Normal Development and Hematopoietic Stem Cell Emergence.

Li C et al.

Cell Reports, 2015

AF9 promotes hESC neural differentiation through recruiting TET2 to neurodevelopmental gene loci for methylcytosine hydroxylation.

Qiao Y et al.

Cell Discovery, 2015

Crystal structure of TET2-DNA complex: insight into TET-mediated 5mC oxidation.

Hu L et al.

Cell, 2013

TET2 promotes histone O-GlcNAcylation during gene transcription.

Chen Q et al.

Nature, 2013

Feature-based classification of amino acid substitutions outside conserved functional protein domains.

Gemovic B et al.

Thescientificworldjournal, 2013

24348198 (PubMed )
Supplement: 948617.f1.pdf

Impaired hydroxylation of 5-methylcytosine in myeloid cancers with mutant TET2.

Ko M et al.

Nature, 2010

21057493 (PubMed )
Supplement: NIHMS247005-supplement-3.pdf
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