Varaico: Literature-Extracted Genetic Variants

Gene:TET2
Variant:p.D1384V
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TET2

NM_001127208.3:p.D1384V

Associated Papers

Clonal haematopoiesis associates with distinct cytometric changes of red blood cells and platelets.

Salzbrunn JB et al.

British Journal of Haematology, 2025

40754673 (PubMed )
Supplement: BJH-207-1085-s002.xlsx › RDW_cohort

Neomorphic leukemia-derived mutations in the TET2 enzyme induce genome instability via a substrate shift from 5-methylcytosine to thymine.

Jin GB et al.

Proceedings of the National Academy of Sciences of the United States of America, 2025

39874291 (PubMed )
Supplement: pnas.2418318122.sapp.pdf

NSUN5/TET2-directed chromatin-associated RNA modification of 5-methylcytosine to 5-hydroxymethylcytosine governs glioma immune evasion.

Wu R et al.

Proceedings of the National Academy of Sciences of the United States of America, 2024

38547058 (PubMed )
Supplement: pnas.2321611121.sapp.pdf

Postazacitidine clone size predicts long-term outcome of patients with myelodysplastic syndromes and related myeloid neoplasms.

Nannya Y et al.

Blood Advances, 2023

36989067 (PubMed )
Supplement: BLOODA_ADV-2022-009564-mmc2.xlsx › SuppTable2

Comprehensive Analysis of Acquired Genetic Variants and Their Prognostic Impact in Systemic Mastocytosis.

González-López O et al.

Cancers, 2022

Sex-Biased ZRSR2 Mutations in Myeloid Malignancies Impair Plasmacytoid Dendritic Cell Activation and Apoptosis.

Togami K et al.

Cancer Discovery, 2022

34615655 (PubMed )
Supplement: cd-20-1513_supplementary_tables_suppst1.xlsx › Supplementary_Table_1

Cellular stressors contribute to the expansion of hematopoietic clones of varying leukemic potential.

Wong TN et al.

Nature Communications, 2018

29386642 (PubMed )
Supplement: 41467_2018_2858_MOESM8_ESM.xlsx › TAML-TMDS

SubcloneSeeker: a computational framework for reconstructing tumor clone structure for cancer variant interpretation and prioritization.

Qiao Y et al.

Genome Biology, 2014

Crystal structure of TET2-DNA complex: insight into TET-mediated 5mC oxidation.

Hu L et al.

Cell, 2013

Clonal evolution of preleukemic hematopoietic stem cells precedes human acute myeloid leukemia.

Jan M et al.

Science Translational Medicine, 2012

TET2 gene mutation is a frequent and adverse event in chronic myelomonocytic leukemia.

Kosmider O et al.

Haematologica, 2009

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."