Associated Papers
MARCH2-mediated Lys63-linked polyubiquitination promotes metastasis by modulating the catalytic activity of TGF-β type I receptor.
Tae K et al.
Cell Death & Disease, 2025
Decoding clinical diversity in monogenic TGFBR1 and TGFBR2 mutations: insights into the interplay of molecular mechanisms and hypomorphicity.
Abu-Sailik F et al.
Frontiers in Cell and Developmental Biology, 2025
The endometrial cancer A230V-ALK5 (TGFBR1) mutant attenuates TGF-β signaling and exhibits reduced in vitro sensitivity to ALK5 inhibitors.
Yu EJ et al.
Plos One, 2024
TGFβ signalling acts as a molecular brake of myoblast fusion.
Melendez J et al.
Nature Communications, 2021
RAC1B Suppresses TGF-β-Dependent Chemokinesis and Growth Inhibition through an Autoregulatory Feed-Forward Loop Involving PAR2 and ALK5.
Otterbein H et al.
Cancers, 2019
Fscn1 is required for the trafficking of TGF-β family type I receptors during endoderm formation.
Liu Z et al.
Nature Communications, 2016
The kinase activity of the Ser/Thr kinase BUB1 promotes TGF-β signaling.
Nyati S et al.
Science Signaling, 2015
TGFBR1 mutations associated with Loeys-Dietz syndrome are inactivating.
Cardoso S et al.
Journal of Receptor and Signal Transduction Research, 2012
Phosphorylation of ΔNp63α via a novel TGFβ/ALK5 signaling mechanism mediates the anti-clonogenic effects of TGFβ.
Cherukuri P et al.
Plos One, 2012
Downregulation of hepatocyte nuclear factor-4alpha and its role in regulation of gene expression by TGF-beta in mammary epithelial cells.
Ishikawa F et al.
Experimental Cell Research, 2008
Somatic acquisition and signaling of TGFBR1*6A in cancer.
Pasche B et al.
Jama, 2005
Interaction and functional interplay between endoglin and ALK-1, two components of the endothelial transforming growth factor-beta receptor complex.
Blanco FJ et al.
Journal of Cellular Physiology, 2005
The novel type I serine-threonine kinase receptor Alk8 binds TGF-beta in the presence of TGF-betaRII.
de Caestecker MP et al.
Biochemical and Biophysical Research Communications, 2002
The type I serine/threonine kinase receptor Alk8/Lost-a-fin is required for Bmp2b/7 signal transduction during dorsoventral patterning of the zebrafish embryo.
Bauer H et al.
Development (cambridge, England), 2001
TGF-beta receptor-mediated signalling through Smad2, Smad3 and Smad4.
Nakao A et al.
The Embo Journal, 1997
Phosphorylation of Ser165 in TGF-beta type I receptor modulates TGF-beta1-induced cellular responses.
Souchelnytskyi S et al.
The Embo Journal, 1996
Interaction of the transforming growth factor-beta type I receptor with farnesyl-protein transferase-alpha.
Kawabata M et al.
The Journal of Biological Chemistry, 1995