Varaico: Literature-Extracted Genetic Variants

Gene:TH
Variant:p.V112M
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TH

NM_199292.3:p.V112M

Associated Papers

Contribution of dopaminergic polymorphisms to levodopa treatment response and drug concentration in Chinese patients with Parkinson's disease.

He X et al.

Clinical Parkinsonism & Related Disorders, 2025

Contribution of Five Functional Loci of Dopamine Metabolism-Related Genes to Parkinson's Disease and Multiple System Atrophy in a Chinese Population.

Chen Y et al.

Frontiers in Neuroscience, 2020

A novel tyrosine hydroxylase variant in a group of Chinese patients with dopa-responsive dystonia.

Yan YP et al.

The International Journal of Neuroscience, 2017

Genetic Variations of Tyrosine Hydroxylase in the Pathogenesis of Hypertension.

Lee YH et al.

Electrolyte & Blood Pressure : E & Bp, 2016

Influence of Dopaminergic System Genetic Variation and Lifestyle Factors on Excessive Alcohol Consumption.

Celorrio D et al.

Alcohol and Alcoholism (oxford, Oxfordshire), 2016

The V81M variant of tyrosine hydroxylase is associated with more severe freezing of gait in Parkinson's disease.

Tekin I et al.

Parkinsonism & Related Disorders, 2016

Polymorphism profiling of nine high altitude relevant candidate gene loci in acclimatized sojourners and adapted natives.

Tomar A et al.

Bmc Genetics, 2015

Evaluation of Hybridization Capture Versus Amplicon-Based Methods for Whole-Exome Sequencing.

Samorodnitsky E et al.

Human Mutation, 2015

26110913 (PubMed )
Supplement: HUMU-36-903-s001.zip › humu22825-sup-00012-Table_S15.xlsx › Sheet1

Functional studies of tyrosine hydroxylase missense variants reveal distinct patterns of molecular defects in Dopa-responsive dystonia.

Fossbakk A et al.

Human Mutation, 2014

Genetics of borderline personality disorder: systematic review and proposal of an integrative model.

Amad A et al.

Neuroscience and Biobehavioral Reviews, 2014

Gaba transporter SLC6A11 gene polymorphism associated with tardive dyskinesia.

Son WY et al.

Nordic Journal of Psychiatry, 2014

Clinical significance of pharmacogenomic studies in tardive dyskinesia associated with patients with psychiatric disorders.

Chang FC et al.

Pharmacogenomics and Personalized Medicine, 2014

Genetic modulation of borderline personality disorder: systematic review and meta-analysis.

Calati R et al.

Journal of Psychiatric Research, 2013

Perspective: Identification of genetic variants associated with dopaminergic compensatory mechanisms in early Parkinson's disease.

Greenbaum L et al.

Frontiers in Neuroscience, 2013

A comparison of Val81Met and other polymorphisms of alcohol metabolising genes in patients and controls in Northern Spain.

Celorrio D et al.

Alcohol (fayetteville, N.y.), 2012

Pharmacogenetics of antidepressant response.

Keers R et al.

Expert Review of Neurotherapeutics, 2011

Pharmacogenetics of antidepressants.

Crisafulli C et al.

Frontiers in Pharmacology, 2011

Human tyrosine hydroxylase natural allelic variation: influence on autonomic function and hypertension.

Rao F et al.

Cellular and Molecular Neurobiology, 2010

Serotonin transporter gene polymorphism associated with short-term treatment response to venlafaxine.

Lee SH et al.

Neuropsychobiology, 2010

Review and meta-analysis of antidepressant pharmacogenetic findings in major depressive disorder.

Kato M et al.

Molecular Psychiatry, 2010

Association analysis between gene variants of the tyrosine hydroxylase and the serotonin transporter in borderline personality disorder.

Tadić A et al.

The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry, 2010

Dopaminergic pathway gene polymorphisms and genetic susceptibility to schizophrenia among north Indians.

Srivastava V et al.

Neuropsychobiology, 2010

Tyrosine hydroxylase Val81Met polymorphism: lack of association with schizophrenia.

Andreou D et al.

Psychiatric Genetics, 2009

Association between Antipsychotics-Induced Restless Legs Syndrome and Tyrosine Hydroxylase Gene Polymorphism.

Cho CH et al.

Psychiatry Investigation, 2009

No Evidence for Association between Tyrosine Hydroxylase Gene Val81Met Polymorphism and Susceptibility to Tardive Dyskinesia in Schizophrenia.

Lee HJ et al.

Psychiatry Investigation, 2009

Molecular epidemiology of major depressive disorder.

Kiyohara C et al.

Environmental Health and Preventive Medicine, 2009

Adrenergic polymorphism and the human stress response.

Rao F et al.

Annals of the New York Academy of Sciences, 2008

Influence of the tyrosine hydroxylase val81met polymorphism and catechol-O-methyltransferase val158met polymorphism on the antidepressant effect of milnacipran.

Yoshida K et al.

Human Psychopharmacology, 2008

Cluster analysis of obsessive-compulsive symptomatology: identifying obsessive-compulsive disorder subtypes.

Lochner C et al.

The Israel Journal of Psychiatry and Related Sciences, 2008

Discovery of common human genetic variants of GTP cyclohydrolase 1 (GCH1) governing nitric oxide, autonomic activity, and cardiovascular risk.

Zhang L et al.

The Journal of Clinical Investigation, 2007

Tyrosine hydroxylase, the rate-limiting enzyme in catecholamine biosynthesis: discovery of common human genetic variants governing transcription, autonomic activity, and blood pressure in vivo.

Rao F et al.

Circulation, 2007

Renal albumin excretion: twin studies identify influences of heredity, environment, and adrenergic pathway polymorphism.

Rao F et al.

Hypertension (dallas, Tex. : 1979), 2007

17353515 (PubMed )
Supplement: sup_zhy081679-s1.pdf

C-reactive protein, an 'intermediate phenotype' for inflammation: human twin studies reveal heritability, association with blood pressure and the metabolic syndrome, and the influence of common polymorphism at catecholaminergic/beta-adrenergic pathway loci.

Wessel J et al.

Journal of Hypertension, 2007

No association of DRD2, DRD3, and tyrosine hydroxylase gene polymorphisms with personality traits in the Japanese population.

Hibino H et al.

Behavioral and Brain Functions : Bbf, 2006

Genetic correlates in trichotillomania--A case-control association study in the South African Caucasian population.

Hemmings SM et al.

The Israel Journal of Psychiatry and Related Sciences, 2006

Functional allelic heterogeneity and pleiotropy of a repeat polymorphism in tyrosine hydroxylase: prediction of catecholamines and response to stress in twins.

Zhang L et al.

Physiological Genomics, 2004

Genetic contributions to Parkinson's disease.

Huang Y et al.

Brain Research. Brain Research Reviews, 2004

Gender in obsessive-compulsive disorder: clinical and genetic findings.

Lochner C et al.

European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology, 2004

Early-onset schizophrenia and dopamine-related gene polymorphism.

Iwata Y et al.

American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics, 2003

Aromatic amino acid hydroxylase genes and schizophrenia.

Chao HM et al.

American Journal of Medical Genetics, 2002

Exon 3 of tyrosine hydroxylase gene: lack of association with Japanese schizophrenic patients.

Ota M et al.

Molecular Psychiatry, 2001

Association analysis of two tyrosine hydroxylase gene polymorphisms in normotensive offspring from hypertensive families.

Jindra A et al.

Blood Pressure, 2000

A review of biochemical and molecular genetic aspects of tyrosine hydroxylase deficiency including a novel mutation (291delC).

Wevers RA et al.

Journal of Inherited Metabolic Disease, 1999

Positive association of tyrosine hydroxylase microsatellite marker to essential hypertension.

Sharma P et al.

Hypertension (dallas, Tex. : 1979), 1998

Systematic search for variations in the tyrosine hydroxylase gene and their associations with schizophrenia, affective disorders, and alcoholism.

Ishiguro H et al.

American Journal of Medical Genetics, 1998

Association study of structural mutations of the tyrosine hydroxylase gene with schizophrenia and Parkinson's disease.

Kunugi H et al.

American Journal of Medical Genetics, 1998

Cluster analysis of obsessive-compulsive spectrum disorders in patients with obsessive-compulsive disorder: clinical and genetic correlates.

Lochner C et al.

Comprehensive Psychiatry, 0

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