Varaico: Literature-Extracted Genetic Variants

Gene:THRB
Variant:p.H435Y
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THRB

NM_001354712.2:p.H435Y

Associated Papers

Discovery of a Potent, Selective, and Multiple His435 Mutation-Sensitive Thyroid Hormone Receptor β Agonist.

Li Q et al.

Journal of Medicinal Chemistry, 2025

The clinical characteristics and gene mutations associated with thyroid hormone resistance syndrome coexisting with pituitary tumors.

Zhao J et al.

Frontiers in Endocrinology, 2023

Discovery of a Highly Selective and H435R-Sensitive Thyroid Hormone Receptor β Agonist.

Li Q et al.

Journal of Medicinal Chemistry, 2022

Variable Clinical Characteristics and Molecular Spectrum of Patients with Syndromes of Reduced Sensitivity to Thyroid Hormone: Genetic Defects in the THRB and SLC16A2 Genes.

Choi JH et al.

Hormone Research in Paediatrics, 2018

A case of resistance to thyroid hormone with thyroid cancer.

Kim HK et al.

Journal of Korean Medical Science, 2010

Selective chemical rescue of a thyroid-hormone-receptor mutant, TRbeta(H435Y), identified in pituitary carcinoma and resistance to thyroid hormone.

Hassan AQ et al.

Angewandte Chemie (international Ed. in English), 2008

Germline and somatic thyroid hormone receptor mutations in man.

Yen PM et al.

Journal of Endocrinological Investigation, 2003

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."