Varaico: Literature-Extracted Genetic Variants

Gene:TLR2
Variant:p.I602S
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TLR2

NM_001318789.2:p.I602S

Associated Papers

Functional CFTR may be required for Prevotella melaninogenica regulation of epithelial cell defense against Staphylococcus aureus.

Goryachok M et al.

Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society, 2025

Toll-like Receptor Gene Polymorphisms as Predictive Biomarkers for Response to Infliximab in Japanese Patients with Crohn's Disease.

Wei J et al.

Diagnostics (basel, Switzerland), 2025

Human genetic diversity regulating the TLR10/TLR1/TLR6 locus confers increased cytokines in response to Chlamydia trachomatis.

Barnes AB et al.

Hgg Advances, 2022

Arg753gln and Arg677 Trp Polymorphisms of Toll-Like Receptor 2 In Acute Apical Abscess.

Miri-Moghaddam E et al.

Journal of Dentistry (shiraz, Iran), 2018

Spatial structure of TLR4 transmembrane domain in bicelles provides the insight into the receptor activation mechanism.

Mineev KS et al.

Scientific Reports, 2017

Methylation of the Vitamin D Receptor (VDR) Gene, Together with Genetic Variation, Race, and Environment Influence the Signaling Efficacy of the Toll-Like Receptor 2/1-VDR Pathway.

Meyer V et al.

Frontiers in Immunology, 2017

Genetic predisposition of variants in TLR2 and its co-receptors to severe malaria in Odisha, India.

Panigrahi S et al.

Immunologic Research, 2016

Toll-like receptor 1(TLR1) Gene SNP rs5743618 is associated with increased risk for tuberculosis in Han Chinese children.

Qi H et al.

Tuberculosis (edinburgh, Scotland), 2015

Less functional variants of TLR-1/-6/-10 genes are associated with age.

Hamann L et al.

Immunity & Ageing : I & A, 2015

Phagocytic and signaling innate immune receptors: are they dysregulated in cystic fibrosis in the fight against Pseudomonas aeruginosa?

Sallenave JM

The International Journal of Biochemistry & Cell Biology, 2014

Haplotype structure and positive selection at TLR1.

Heffelfinger C et al.

European Journal of Human Genetics : Ejhg, 2014

Cystic fibrosis CFBE41o- cells contain TLR1 SNP I602S and fail to respond to Mycobacterium abscessus.

Kempaiah P et al.

Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society, 2013

Toll-like receptors and human disease: lessons from single nucleotide polymorphisms.

Lin YT et al.

Current Genomics, 2012

Human TOLLIP regulates TLR2 and TLR4 signaling and its polymorphisms are associated with susceptibility to tuberculosis.

Shah JA et al.

Journal of Immunology (baltimore, Md. : 1950), 2012

Susceptibility to tuberculosis is associated with TLR1 polymorphisms resulting in a lack of TLR1 cell surface expression.

Uciechowski P et al.

Journal of Leukocyte Biology, 2011

[Molecular characterization of embB306 gene in Mycobacterium tuberculosis isolates from tuberculosis patients in Chongqing municipality].

Lin H et al.

Zhonghua Yu Fang Yi Xue Za Zhi [chinese Journal of Preventive Medicine], 2009

Variants in the toll-like receptor signaling pathway and clinical outcomes of malaria.

Leoratti FM et al.

The Journal of Infectious Diseases, 2008

Human TLR1 deficiency is associated with impaired mycobacterial signaling and protection from leprosy reversal reaction.

Misch EA et al.

Plos Neglected Tropical Diseases, 2008

A common human TLR1 polymorphism regulates the innate immune response to lipopeptides.

Hawn TR et al.

European Journal of Immunology, 2007

Genomic variants of TLR1--it takes (TLR-)two to tango.

Schumann RR et al.

European Journal of Immunology, 2007

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."