Varaico: Literature-Extracted Genetic Variants

Gene:TLR2
Variant:p.P631H
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TLR2

NM_001318789.2:p.P631H

Associated Papers

Toll-like receptor 3 (TLR 3) polymorphisms predisposition to schizophrenia and bipolar disorder.

Aflouk Y et al.

Molecular Biology Reports, 2025

The Role of TLR2/TLR4 Receptors in Host Genetic Susceptibility to Recurrent Vulvovaginitis.

Routsias J et al.

Journal of Fungi (basel, Switzerland), 2025

The evolutionary landscape of host immunity genes involved in respiratory and other immune-related diseases, and their association with severe COVID-19 outcomes.

Cross CN et al.

Medrxiv : the Preprint Server for Health Sciences, 2025

Genetic Predisposition of TLR 1 and TLR 6 Polymorphisms to Schizophrenia Onset and Prediction of Treatment Response.

Aflouk Y et al.

Biochemical Genetics, 2025

Exome Profiling Suggests Combined Effect of Myeloperoxidase, Toll-Like Receptors, and Metallopeptidase in Hidradenitis Suppurativa.

Azzarà A et al.

Biomedicines, 2024

Immunogenetics of Systemic Sclerosis.

Gumkowska-Sroka O et al.

Genes, 2024

Relevance of Coding Variation in FLG And DOCK8 in Finnish Pediatric Patients with Early-Onset Moderate-To-Severe Atopic Dermatitis.

Perälä M et al.

Jid Innovations : Skin Science From Molecules to Population Health, 2023

37533579 (PubMed )
Supplement: mmc1.xlsx › Supplementary_Table_S1

Myeloid lineage cells evince distinct steady-state level of certain gene groups in dependence on hereditary angioedema severity.

Ballonová L et al.

Frontiers in Genetics, 2023

37470035 (PubMed )
Supplement: Table1.XLSX › Table_S3_Deleterious_gene_varia

Association between TLR2 polymorphisms (- 196-174 Ins/Del, R677W, R753Q, and P631H) and schizophrenia in a Tunisian population.

Aflouk Y et al.

Immunologic Research, 2021

Why does SARS-CoV-2 hit in different ways? Host genetic factors can influence the acquisition or the course of COVID-19.

Monticelli M et al.

European Journal of Medical Genetics, 2021

Polymorphisms in vitamin D receptor, toll-like receptor 2 and Toll-Like receptor 4 genes links with Dengue susceptibility.

Singh AK et al.

Bioinformation, 2021

Genotype Frequency of the Common TLR4 SNPs in a Kurdish Population: Global Reviews and Out-of-African Migrations.

Niranji SS et al.

Human Biology, 2021

Association of toll-like receptor polymorphisms with acquisition of HIV infection and clinical findings: A protocol for systematic review and meta-analysis.

Shi H et al.

Medicine, 2020

The Arg753Gln Polymorphism of Toll-Like Receptor 2 Has a Lower Occurrence in Patients with Syphilis, Suggesting Its Protective Effect in Czech and Slovak Individuals.

Grillová L et al.

Infection and Immunity, 2020

Toll-like receptor polymorphism in host immune response to infectious diseases: A review.

Mukherjee S et al.

Scandinavian Journal of Immunology, 2019

Pattern recognition receptor polymorphisms in early periodontitis.

Leite FRM et al.

Journal of Periodontology, 2019

Host genetic variants in sepsis risk: a field synopsis and meta-analysis.

Lu H et al.

Critical Care (london, England), 2019

30683156 (PubMed )
Supplement: 13054_2019_2313_MOESM3_ESM.docx

Genomic analysis reveals recurrent deletion of JAK-STAT signaling inhibitors HNRNPK and SOCS1 in mycosis fungoides.

Bastidas Torres AN et al.

Genes, Chromosomes & Cancer, 2018

30144205 (PubMed )
Supplement: GCC-57-653-s002.xlsx › 12

Functional polymorphisms of innate immunity receptors are not risk factors for the non-SBP type bacterial infections in cirrhosis.

Dinya T et al.

Liver International : Official Journal of the International Association for the Study of the Liver, 2018

Influence of polymorphisms in toll-like receptors (TLRs) on malaria susceptibility in low-endemic area of the Atlantic Forest, São Paulo, Brazil.

Guimarães LO et al.

Acta Tropica, 2018

Genetic ancestry effects on the distribution of toll-like receptors (TLRs) gene polymorphisms in a population of the Atlantic Forest, São Paulo, Brazil.

Guimarães LO et al.

Human Immunology, 2018

Validation of CZECANCA (CZEch CAncer paNel for Clinical Application) for targeted NGS-based analysis of hereditary cancer syndromes.

Soukupova J et al.

Plos One, 2018

29649263 (PubMed )
Supplement: pone.0195761.s005.xlsx › S5

No associations established between single nucleotide polymorphisms in human Toll-like receptor 2 and Toll-interacting protein and Staphylococcus aureus bloodstream infections.

Smeland TE et al.

Apmis : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica, 2017

Human genetic factors in tuberculosis: an update.

van Tong H et al.

Tropical Medicine & International Health : Tm & Ih, 2017

Susceptibility to HIV-1 infection is influenced by toll like receptor-2 (-196 to -174) polymorphism in a north Indian population.

Vidyant S et al.

The Journal of Gene Medicine, 2017

Evaluation of Toll-like-receptor gene family variants as prognostic biomarkers in rheumatoid arthritis.

Torices S et al.

Immunology Letters, 2017

The R753Q polymorphism in Toll-like receptor 2 (TLR2) attenuates innate immune responses to mycobacteria and impairs MyD88 adapter recruitment to TLR2.

Pattabiraman G et al.

The Journal of Biological Chemistry, 2017

TLR2 polymorphism and susceptibility to vulvovaginal colonisation by Candida species.

Colombo R et al.

Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology, 2017

Genetic variation of the Toll-like receptors in a Swedish allergic rhinitis case population.

Henmyr V et al.

Bmc Medical Genetics, 2017

28228119 (PubMed )
Supplement: 12881_2017_379_MOESM8_ESM.xlsx › TabS4

Vitamin D status, vitamin D receptor and toll like receptor-2 polymorphisms in tuberculous meningitis: a case-control study.

Rizvi I et al.

Infection, 2016

Cell line donor genotype and its influence on experimental phenotype: Toll-like receptor SNPs and potential variability in innate immunity.

Tokarz SA et al.

Molecular Genetics and Metabolism, 2016

Characterization of Disease-Associated Mutations in Human Transmembrane Proteins.

Molnár J et al.

Plos One, 2016

26986070 (PubMed )
Supplement: pone.0151760.s001.xlsx › polymorphism

Gene/environment interactions in the pathogenesis of autoimmunity: new insights on the role of Toll-like receptors.

Gianchecchi E et al.

Autoimmunity Reviews, 2015

Genetic Variation in Pattern Recognition Receptors and Adaptor Proteins Associated With Development of Chronic Q Fever.

Schoffelen T et al.

The Journal of Infectious Diseases, 2015

Association of Toll-like receptor 2 Arg753Gln and Toll-like receptor 1 Ile602Ser single-nucleotide polymorphisms with leptospirosis in an Argentine population.

Cédola M et al.

Acta Tropica, 2015

Association of TLR1, TLR2, TLR4, TLR6, and TIRAP polymorphisms with disease susceptibility.

Noreen M et al.

Immunologic Research, 2015

The role of Toll-like receptor polymorphisms in acute pancreatitis occurrence and severity.

Matas-Cobos AM et al.

Pancreas, 2015

Recognition of Coxiella burnetii by toll-like receptors and nucleotide-binding oligomerization domain-like receptors.

Ammerdorffer A et al.

The Journal of Infectious Diseases, 2015

Lack of Association between Toll Like Receptor-2 and Toll Like Receptor-4 Gene Polymorphisms and Other Feature in Iranian Asthmatics Patients.

Bahrami H et al.

Iranian Journal of Allergy, Asthma, and Immunology, 2015

Emerging roles of innate immune signaling and toll-like receptors in fibrosis and systemic sclerosis.

Bhattacharyya S et al.

Current Rheumatology Reports, 2015

TLR1, 2, 4, 6 and 9 Variants Associated with Tuberculosis Susceptibility: A Systematic Review and Meta-Analysis.

Schurz H et al.

Plos One, 2015

26430737 (PubMed )
Supplement: pone.0139711.s005.xlsx › S1_Table

The eSNV-detect: a computational system to identify expressed single nucleotide variants from transcriptome sequencing data.

Tang X et al.

Nucleic Acids Research, 2014

25352556 (PubMed )
Supplement: supp_gku1005_nar-01266-met-n-2014-File012.xlsx › TCGA-AN-A049-01A.domain

TLR1, TLR2, and TLR6 gene polymorphisms are associated with increased susceptibility to complicated skin and skin structure infections.

Stappers MH et al.

The Journal of Infectious Diseases, 2014

Host genome polymorphisms and tuberculosis infection: What we have to say?

Khalilullah SA et al.

The Egyptian Journal of Chest Diseases and Tuberculosis, 2014

Gene polymorphisms in pattern recognition receptors and susceptibility to idiopathic recurrent vulvovaginal candidiasis.

Rosentul DC et al.

Frontiers in Microbiology, 2014

[Review of the relationship between human TLR9 gene polymorphisms and infectious diseases].

Cheng RD et al.

Zhonghua Er Ke Za Zhi = Chinese Journal of Pediatrics, 2013

Toll-like receptor polymorphisms, inflammatory and infectious diseases, allergies, and cancer.

Medvedev AE

Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research, 2013

Influence of Intron II microsatellite polymorphism in human toll-like receptor 2 gene in leprosy.

Suryadevara NC et al.

Human Immunology, 2013

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