Associated Papers
Structural characterization of TIR-domain signalosomes through a combination of structural biology approaches.
Bhatt A et al.
Iucrj, 2024
TLR2 2029C/T and TLR3 1377C/T and -7C/A Polymorphisms Are Associated with the Occurrence of Abdominal Aortic Aneurysm.
Jabłońska A et al.
Journal of Immunology (baltimore, Md. : 1950), 2020
Probing subtle conformational changes induced by phosphorylation and point mutations in the TIR domains of TLR2 and TLR3.
Mahita J et al.
Proteins, 2018
Investigating the effect of key mutations on the conformational dynamics of toll-like receptor dimers through molecular dynamics simulations and protein structure networks.
Mahita J et al.
Proteins, 2018
Toll-like receptor polymorphisms compromise the inflammatory response against bacterial antigen translocation in cirrhosis.
Piñero P et al.
Scientific Reports, 2017
Conformational dynamics of cancer-associated MyD88-TIR domain mutant L252P (L265P) allosterically tilts the landscape toward homo-dimerization.
Zhan C et al.
Protein Engineering, Design & Selection : Peds, 2016
An alanine-to-proline mutation in the BB-loop of TLR3 Toll/IL-1R domain switches signalling adaptor specificity from TRIF to MyD88.
Verstak B et al.
Journal of Immunology (baltimore, Md. : 1950), 2013
Influence of Toll-like receptor gene polymorphisms to tuberculosis susceptibility in humans.
Thada S et al.
Scandinavian Journal of Immunology, 2013
Toll-like receptor polymorphisms, inflammatory and infectious diseases, allergies, and cancer.
Medvedev AE
Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research, 2013
R753Q polymorphism inhibits Toll-like receptor (TLR) 2 tyrosine phosphorylation, dimerization with TLR6, and recruitment of myeloid differentiation primary response protein 88.
Xiong Y et al.
The Journal of Biological Chemistry, 2012
The structural biology of Toll-like receptors.
Botos I et al.
Structure (london, England : 1993), 2011
Toll-like receptor 2 (P631H) mutant impairs membrane internalization and is a dominant negative allele.
Etokebe GE et al.
Scandinavian Journal of Immunology, 2010
The heterogeneous allelic repertoire of human toll-like receptor (TLR) genes.
Georgel P et al.
Plos One, 2009
TLR2 polymorphisms, Arg753Gln and Arg677Trp, are not associated with increased burden of tuberculosis in Indian patients.
Biswas D et al.
Bmc Research Notes, 2009
Novel mutations in TLR genes cause hyporesponsiveness to Mycobacterium avium subsp. paratuberculosis infection.
Bhide MR et al.
Bmc Genetics, 2009
Toll-like receptors TLR1, TLR2 and TLR4 gene mutations and natural resistance to Mycobacterium avium subsp. paratuberculosis infection in cattle.
Mucha R et al.
Veterinary Immunology and Immunopathology, 2009
Pathogen recognition by Toll-like receptor 2 activates Weibel-Palade body exocytosis in human aortic endothelial cells.
Into T et al.
The Journal of Biological Chemistry, 2007
Structural and functional evidence for the role of the TLR2 DD loop in TLR1/TLR2 heterodimerization and signaling.
Gautam JK et al.
The Journal of Biological Chemistry, 2006
Binding specificity of Toll-like receptor cytoplasmic domains.
Brown V et al.
European Journal of Immunology, 2006
The importance of Toll-like receptor 2 polymorphisms in severe infections.
Texereau J et al.
Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America, 2005
Toll-like receptor 2 Arg677Trp polymorphism is associated with susceptibility to tuberculosis in Tunisian patients.
Ben-Ali M et al.
Clinical and Diagnostic Laboratory Immunology, 2004
The Arg753GLn polymorphism of the human toll-like receptor 2 gene in tuberculosis disease.
Ogus AC et al.
The European Respiratory Journal, 2004
The interleukin 1 (IL-1) receptor accessory protein Toll/IL-1 receptor domain: analysis of putative interaction sites in vitro mutagenesis and molecular modeling.
Radons J et al.
The Journal of Biological Chemistry, 2003
Cutting edge: a Toll-like receptor 2 polymorphism that is associated with lepromatous leprosy is unable to mediate mycobacterial signaling.
Bochud PY et al.
Journal of Immunology (baltimore, Md. : 1950), 2003
An extensively associated dimer in the structure of the C713S mutant of the TIR domain of human TLR2.
Tao X et al.
Biochemical and Biophysical Research Communications, 2002
Detection of Toll-like receptor 2 (TLR2) mutation in the lepromatous leprosy patients.
Kang TJ et al.
Fems Immunology and Medical Microbiology, 2001
Structural basis for signal transduction by the Toll/interleukin-1 receptor domains.
Xu Y et al.
Nature, 2000