Associated Papers
Structural characterization of TIR-domain signalosomes through a combination of structural biology approaches.
Bhatt A et al.
Iucrj, 2024
39190506 (PubMed )
Supplement: m-11-00695-sup1.pdf
Structure of a prokaryotic SEFIR domain reveals two novel SEFIR-SEFIR interaction modes.
Yang H et al.
Journal of Structural Biology, 2018
Conformational dynamics of cancer-associated MyD88-TIR domain mutant L252P (L265P) allosterically tilts the landscape toward homo-dimerization.
Zhan C et al.
Protein Engineering, Design & Selection : Peds, 2016
The Architecture of the TIR Domain Signalosome in the Toll-like Receptor-4 Signaling Pathway.
Guven-Maiorov E et al.
Scientific Reports, 2015
Identification of interaction sites for dimerization and adapter recruitment in Toll/interleukin-1 receptor (TIR) domain of Toll-like receptor 4.
Bovijn C et al.
The Journal of Biological Chemistry, 2012
TAK-242 (resatorvid), a small-molecule inhibitor of Toll-like receptor (TLR) 4 signaling, binds selectively to TLR4 and interferes with interactions between TLR4 and its adaptor molecules.
Matsunaga N et al.
Molecular Pharmacology, 2011
The crystal structure of the human toll-like receptor 10 cytoplasmic domain reveals a putative signaling dimer.
Nyman T et al.
The Journal of Biological Chemistry, 2008
Structural and functional evidence for the role of the TLR2 DD loop in TLR1/TLR2 heterodimerization and signaling.
Gautam JK et al.
The Journal of Biological Chemistry, 2006
An extensively associated dimer in the structure of the C713S mutant of the TIR domain of human TLR2.
Tao X et al.
Biochemical and Biophysical Research Communications, 2002
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