Varaico: Literature-Extracted Genetic Variants

Gene:TLR3
Variant:p.L412F
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TLR3

NM_003265.3:p.L412F

Associated Papers

Genome-wide association analyses of autoimmune hypothyroidism reveal autoimmune and thyroid-specific contributions and an inverse relationship with cancer risk.

Reeve MP et al.

Nature Genetics, 2026

Host genetic factors modulating dengue virus: a systematic review of TLR polymorphisms.

Candrasari DS et al.

Bmc Infectious Diseases, 2026

Association of immune relevant single nucleotide polymorphisms with ALK-positive anaplastic large cell lymphoma presentation and outcome: results of the immuno ALCL study.

Adriana P et al.

Journal of Translational Medicine, 2025

Toll-like receptor 3 (TLR 3) polymorphisms predisposition to schizophrenia and bipolar disorder.

Aflouk Y et al.

Molecular Biology Reports, 2025

The Role of TLR2/TLR4 Receptors in Host Genetic Susceptibility to Recurrent Vulvovaginitis.

Routsias J et al.

Journal of Fungi (basel, Switzerland), 2025

A tiered strategy to identify relevant genetic variants in familial pulmonary fibrosis: a proof of concept for the clinical practice.

Alonso-González A et al.

European Journal of Human Genetics : Ejhg, 2025

39748130 (PubMed )
Supplement: 41431_2024_1772_MOESM1_ESM.docx

The Role of TLR3 rs3775291 Variant in West Nile Virus Infection: A Case-Control Study.

Bashiardes S et al.

Microorganisms, 2025

The X-Linked TLR7 rs179008 T Allele Is Associated with an Increased Risk of Severe Multisystem Inflammatory Syndrome in Children/Kawasaki-like Syndrome in SARS-CoV-2-Infected Boys.

Andrade AS et al.

International Journal of Molecular Sciences, 2025

Association of TLR3 1337C/T and 1234C/T polymorphisms with chronic hepatitis B virus infection in Sudanese patients: A case-control study.

Elyass K et al.

The Journal of International Medical Research, 2025

Toll-like receptors polymorphisms and COVID-19: a systematic review.

Dos Santos BRC et al.

Molecular and Cellular Biochemistry, 2025

The pharmacogenomic landscape in the Chinese: An analytics of pharmacogenetic variants in 206,640 individuals.

Wang LY et al.

Innovation (cambridge (mass.)), 2025

39991480 (PubMed )
Supplement: mmc5.xlsx › Sheet1

Features of toll-like receptor genes (TLR-2, TLR-3, TLR-4 and TLR-6) polymorphism in open-angle glaucoma patients.

Shevchenko AV et al.

Vavilovskii Zhurnal Genetiki I Selektsii, 2025

X-linked polymorphisms in TLR7 and TLR8 genes are associated with protection against Chikungunya fever.

Gotay WJP et al.

Memorias Do Instituto Oswaldo Cruz, 2025

TLR3 rs3775291 C/T polymorphism is associated with elevated IFN-α level in asymptomatic HTLV-1 infection.

Ferreira FDS et al.

Frontiers in Cellular and Infection Microbiology, 2025

The role of inflammatory gene polymorphisms in severe COVID-19: a review.

Yip JQ et al.

Virology Journal, 2024

Concomitant Ultrarare Mutations in TLR3 and CTPS2 in a Patient with Severe and Recurrent Respiratory Infections in Early Life.

Bougarn S et al.

Journal of Clinical Immunology, 2024

39312089 (PubMed )
Supplement: 10875_2024_1804_MOESM1_ESM.docx

Genetic polymorphisms of TLR1, TLR2, TLR3 and TLR4 in patients with recurrent or severe infections.

Teräsjärvi J et al.

International Journal of Immunogenetics, 2024

Start codon variant in LAG3 is associated with decreased LAG-3 expression and increased risk of autoimmune thyroid disease.

Saevarsdottir S et al.

Nature Communications, 2024

38982041 (PubMed )
Supplement: 41467_2024_50007_MOESM4_ESM.xlsx › SD3

Association between polymorphisms in TLR3, TICAM1 and IFNA1 genes and covid-19 severity in Southern Brazil.

Braga M et al.

Expert Review of Molecular Diagnostics, 2024

Toll-Like receptor 3 genetic polymorphism in dengue encephalitis.

Verma R et al.

Journal of Family Medicine and Primary Care, 2024

Genomic alterations in ovarian endometriosis and subsequently diagnosed ovarian carcinoma.

Linder A et al.

Human Reproduction (oxford, England), 2024

38459814 (PubMed )
Supplement: deae043_supplementary_table_s3.xlsx › Endometriosis

ACE Phenotyping in Human Blood and Tissues: Revelation of ACE Outliers and Sex Differences in ACE Sialylation.

Enyedi EE et al.

Biomedicines, 2024

38790902 (PubMed )
Supplement: biomedicines-12-00940-s001.zip › biomedicines-2930173-supplementary.pdf

The contribution of pattern recognition receptor signalling in the development of age related macular degeneration: the role of toll-like-receptors and the NLRP3-inflammasome.

Brandli A et al.

Journal of Neuroinflammation, 2024

Evolutionary history of adenomas to colorectal cancer in FAP families.

Yang C et al.

Frontiers in Genetics, 2024

39021676 (PubMed )
Supplement: DataSheet1.ZIP › Somatic › 18R12365.xls › SNVIndel

Identification of a Novel NLRP12 Frameshift Mutation (Val730Glyfs∗41) by Whole-Exome Sequencing in Patients with Crohn's Disease.

Chen J et al.

Human Mutation, 2024

40225939 (PubMed )
Supplement: 5573272.f1.docx

Indicators of HSV1 Infection, ECM-Receptor Interaction, and Chromatin Modulation in a Nuclear Family with Schizophrenia.

Huang YC et al.

Journal of Personalized Medicine, 2023

Recent advances in the genetics of idiopathic pulmonary fibrosis.

Spagnolo P et al.

Current Opinion in Pulmonary Medicine, 2023

The TLR3 L412F polymorphism prevents TLR3-mediated tumor cell death induction in pediatric sarcomas.

Bisaccia J et al.

Cell Death Discovery, 2023

The Relationship between TLR3 rs3775291 Polymorphism and Infectious Diseases: A Meta-Analysis of Case-Control Studies.

Silva MJA et al.

Genes, 2023

Association of Toll-Like Receptor 3 Polymorphisms with Kaposi's Sarcoma-Associated Herpesvirus Infection Among Human Immunodeficiency Virus-Infected Individuals in Xinjiang, China.

Zhang X et al.

Viral Immunology, 2023

TLRs: Innate Immune Sentries against SARS-CoV-2 Infection.

Mantovani S et al.

International Journal of Molecular Sciences, 2023

Potential Impact of Polymorphisms in Toll-like Receptors 2, 3, 4, 7, 9, miR-146a, miR-155, and miR-196a Genes on Osteoarthritis Susceptibility.

Stefik D et al.

Biology, 2023

Genetic adaptation to pathogens and increased risk of inflammatory disorders in post-Neolithic Europe.

Kerner G et al.

Cell Genomics, 2023

36819665 (PubMed )
Supplement: mmc2.pdf

Functional link between sarcoidosis-associated gene variants and quantitative levels of bronchoalveolar lavage fluid cell types.

Abo Al Hayja M et al.

Frontiers in Medicine, 2023

Analysis of associations between the TLR3 SNPs rs3775291 and rs3775290 and COVID-19 in a cohort of professionals of Belém-PA, Brazil.

Silva MJA et al.

Frontiers in Cellular and Infection Microbiology, 2023

Association of Toll-like receptor-4 polymorphism with SARS CoV-2 infection in Kurdish Population.

Ali HN et al.

Human Gene (amsterdam, Netherlands), 2022

Systematic review and meta-analysis of human genetic variants contributing to COVID-19 susceptibility and severity.

Gupta K et al.

Gene, 2022

Genetic Polymorphism in Toll-Like Receptor 3 and Interferon Regulatory Factor 3 in Hepatitis C Virus-Infected Patients: Correlation with Liver Cirrhosis.

Talaat RM et al.

Viral Immunology, 2022

Polymorphisms in toll-like receptor 3 and 4 genes as prognostic and outcome biomarkers in melanoma patients.

Ostojic N et al.

Melanoma Research, 2022

Host genetic basis of COVID-19: from methodologies to genes.

Zguro K et al.

European Journal of Human Genetics : Ejhg, 2022

Genetic polymorphisms in TLR3, IL10 and CD209 influence the risk of BK polyomavirus infection after kidney transplantation.

Redondo N et al.

Scientific Reports, 2022

The polymorphism L412F in TLR3 inhibits autophagy and is a marker of severe COVID-19 in males.

Croci S et al.

Autophagy, 2022

Variations within Toll-like receptor (TLR) and TLR signaling pathway-related genes and their synergistic effects on the risk of Guillain-Barré syndrome.

Dutta D et al.

Journal of the Peripheral Nervous System : Jpns, 2022

Life-Threatening Enterovirus 71 Encephalitis in Unrelated Children with Autosomal Dominant TLR3 Deficiency.

Kuo CY et al.

Journal of Clinical Immunology, 2022

Common, low-frequency, rare, and ultra-rare coding variants contribute to COVID-19 severity.

Fallerini C et al.

Human Genetics, 2022

Exome Sequencing Reveals Genetic Variability and Identifies Chronic Prognostic Loci in Chinese Sarcoidosis Patients.

Zhang Q et al.

Frontiers in Oncology, 2022

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."