Associated Papers
TRPC channels blockade abolishes endotoxemic cardiac dysfunction by hampering intracellular inflammation and Ca2+ leakage.
Tang N et al.
Nature Communications, 2022
Flow cytometric reporter assays provide robust functional analysis of signaling complexes.
Muusse TW et al.
The Journal of Biological Chemistry, 2022
Probing subtle conformational changes induced by phosphorylation and point mutations in the TIR domains of TLR2 and TLR3.
Mahita J et al.
Proteins, 2018
LPS receptor subunits have antagonistic roles in epithelial apoptosis and colonic carcinogenesis.
Kuo WT et al.
Cell Death and Differentiation, 2015
Three conserved MyD88-recruiting TLR residues exert different effects on the human TLR4 signaling pathway.
Ding Y et al.
Immunologic Research, 2015
Poxviral protein A46 antagonizes Toll-like receptor 4 signaling by targeting BB loop motifs in Toll-IL-1 receptor adaptor proteins to disrupt receptor:adaptor interactions.
Stack J et al.
The Journal of Biological Chemistry, 2012
Identification of interaction sites for dimerization and adapter recruitment in Toll/interleukin-1 receptor (TIR) domain of Toll-like receptor 4.
Bovijn C et al.
The Journal of Biological Chemistry, 2012
TLR4/MyD88/PI3K interactions regulate TLR4 signaling.
Laird MH et al.
Journal of Leukocyte Biology, 2009
Analysis of the functional role of Toll-like receptor-4 tyrosine phosphorylation.
Medvedev AE et al.
Methods in Molecular Biology (clifton, N.j.), 2009
Homo-oligomerization is essential for Toll/interleukin-1 receptor domain-containing adaptor molecule-1-mediated NF-kappaB and interferon regulatory factor-3 activation.
Funami K et al.
The Journal of Biological Chemistry, 2008
The crystal structure of the human toll-like receptor 10 cytoplasmic domain reveals a putative signaling dimer.
Nyman T et al.
The Journal of Biological Chemistry, 2008
Tyrosine phosphorylation of MyD88 adapter-like (Mal) is critical for signal transduction and blocked in endotoxin tolerance.
Piao W et al.
The Journal of Biological Chemistry, 2008
A dimer of the Toll-like receptor 4 cytoplasmic domain provides a specific scaffold for the recruitment of signalling adaptor proteins.
Núñez Miguel R et al.
Plos One, 2007
Role of TLR4 tyrosine phosphorylation in signal transduction and endotoxin tolerance.
Medvedev AE et al.
The Journal of Biological Chemistry, 2007
Functional cell permeable motifs within medically relevant proteins.
Low W et al.
Journal of Biotechnology, 2007
Toll-like receptor 4 region Glu24-Lys47 is a site for MD-2 binding: importance of CYS29 and CYS40.
Nishitani C et al.
The Journal of Biological Chemistry, 2006
Structural and functional evidence for the role of the TLR2 DD loop in TLR1/TLR2 heterodimerization and signaling.
Gautam JK et al.
The Journal of Biological Chemistry, 2006
TICAM-1 and TICAM-2: toll-like receptor adapters that participate in induction of type 1 interferons.
Seya T et al.
The International Journal of Biochemistry & Cell Biology, 2005