Associated Papers
Identification of a novel TLR7 gain-of-function variant that underlies systemic lupus erythematosus.
Sethumadhavan A et al.
Journal of Human Immunity, 2026
Recent insights into the role of innate immunity in lupus.
Robinson LA et al.
Human Molecular Genetics, 2025
Common Toll-like receptor 7 variants define disease risk and phenotypes in juvenile-onset systemic lupus erythematosus.
Renaudineau Y et al.
Journal of Autoimmunity, 2025
From Rare to Common: Genetic Insights into TLR7 Variants in a Multicentric Spanish Study on COVID-19 Severity.
Antolí A et al.
Journal of Clinical Immunology, 2025
Somatic gain-of-function mutation in TLR7 causes early-onset systemic lupus erythematosus.
Zeng Y et al.
Annals of the Rheumatic Diseases, 2025
Primary immunodeficiency as a cause of immune-mediated kidney diseases.
Zhang C et al.
Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association, 2024
Refractory Autoimmune Thrombocytopenia in an Infant with a De Novo TLR7 Gain-of-Function Variant.
Menon S et al.
Journal of Clinical Immunology, 2024
UNCovering new causes of monogenic systemic lupus erythematosus.
Ellyard JI et al.
Immunology and Cell Biology, 2024
Polymorphism in the leucine-rich repeats of TLR7 in different breeds of chicken and in silico analysis of its effect on TLR7 structure and function.
Kaliappan A et al.
Gene, 2024
A de novo TLR7 gain-of-function mutation causing severe monogenic lupus in an infant.
Stremenova Spegarova J et al.
The Journal of Clinical Investigation, 2024
Human and Murine Toll-like Receptor-Driven Disease in Systemic Lupus Erythematosus.
von Hofsten S et al.
International Journal of Molecular Sciences, 2024
Altered X-chromosome inactivation predisposes to autoimmunity.
Huret C et al.
Science Advances, 2024
Interface Gain-of-Function Mutations in TLR7 Cause Systemic and Neuro-inflammatory Disease.
David C et al.
Journal of Clinical Immunology, 2024
Genetic interrogation for sequence and copy number variants in systemic lupus erythematosus.
Yeo NK et al.
Frontiers in Genetics, 2024
TLR8 escapes X chromosome inactivation in human monocytes and CD4+ T cells.
Youness A et al.
Biology of Sex Differences, 2023
Genetics of SLE: mechanistic insights from monogenic disease and disease-associated variants.
Vinuesa CG et al.
Nature Reviews. Nephrology, 2023
Monogenic lupus: Tracing the therapeutic implications from single gene mutations.
Jia X et al.
Clinical Immunology (orlando, Fla.), 2023
Gain-of-function TLR7 and loss-of-function A20 gene variants identify a novel pathway for Mendelian lupus and lupus nephritis.
Villalvazo P et al.
Clinical Kidney Journal, 2022
TLR7 gain-of-function genetic variation causes human lupus.
Brown GJ et al.
Nature, 2022