Varaico: Literature-Extracted Genetic Variants

Gene:TLR9
Variant:p.M400I
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TLR9

NM_017442.4:p.M400I

Associated Papers

Leucine-rich repeat 11 of Toll-like receptor 9 can tightly bind to CpG-containing oligodeoxynucleotides, and the positively charged residues are critical for the high affinity.

Pan X et al.

The Journal of Biological Chemistry, 2012

Heterozygous carriage of a dysfunctional Toll-like receptor 9 allele affects CpG oligonucleotide responses in B cells.

Knezević J et al.

The Journal of Biological Chemistry, 2012

A naturally occurring variant in human TLR9, P99L, is associated with loss of CpG oligonucleotide responsiveness.

Kubarenko AV et al.

The Journal of Biological Chemistry, 2010

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."