Varaico: Literature-Extracted Genetic Variants

Gene:TLR9
Variant:p.P99L
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TLR9

NM_017442.4:p.P99L

Associated Papers

Mutated Toll-like receptor 9 increases Alzheimer's disease risk by compromising innate immunity protection.

Cacace R et al.

Molecular Psychiatry, 2023

Toll-like receptor polymorphism in host immune response to infectious diseases: A review.

Mukherjee S et al.

Scandinavian Journal of Immunology, 2019

Association of TLR4 and TLR9 gene polymorphisms and haplotypes with cervicitis susceptibility.

Chauhan A et al.

Plos One, 2019

Absence of toll-like receptor 9 Pro99Leu polymorphism in cervical cancer.

Chauhan A et al.

F1000research, 2018

Genetic variation of the Toll-like receptors in a Swedish allergic rhinitis case population.

Henmyr V et al.

Bmc Medical Genetics, 2017

28228119 (PubMed )
Supplement: 12881_2017_379_MOESM8_ESM.xlsx › TabS4

Structural basis of CpG and inhibitory DNA recognition by Toll-like receptor 9.

Ohto U et al.

Nature, 2015

Toll-like receptors and human disease: lessons from single nucleotide polymorphisms.

Lin YT et al.

Current Genomics, 2012

Leucine-rich repeat 11 of Toll-like receptor 9 can tightly bind to CpG-containing oligodeoxynucleotides, and the positively charged residues are critical for the high affinity.

Pan X et al.

The Journal of Biological Chemistry, 2012

Heterozygous carriage of a dysfunctional Toll-like receptor 9 allele affects CpG oligonucleotide responses in B cells.

Knezević J et al.

The Journal of Biological Chemistry, 2012

The T-1237C polymorphism of the Toll-like receptor-9 gene is associated with chronic kidney disease in a Han Chinese population.

Lu KC et al.

The Tohoku Journal of Experimental Medicine, 2011

A naturally occurring variant in human TLR9, P99L, is associated with loss of CpG oligonucleotide responsiveness.

Kubarenko AV et al.

The Journal of Biological Chemistry, 2010

Single-nucleotide polymorphisms in the Toll-like receptor 9 gene (TLR9): frequencies, pairwise linkage disequilibrium, and haplotypes in three U.S. ethnic groups and exploratory case-control disease association studies.

Lazarus R et al.

Genomics, 2003

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."