Varaico: Literature-Extracted Genetic Variants

Gene:TNFRSF10A
Variant:p.E228A
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TNFRSF10A

NM_003844.4:p.E228A

Associated Papers

The Contribution of Genetic Modifiers to Ovarian Cancer Risk in BRCA1 and BRCA2 Pathogenic Variant Carriers.

Cylwik D et al.

Cancers, 2026

Genetic susceptibility of bladder cancer in the Lebanese population.

Kourie HR et al.

Bmc Medical Genomics, 2022

36253817 (PubMed )
Supplement: 12920_2022_1372_MOESM1_ESM.xlsx › sheet_1

Genetic variations in tumor ecrosis factor related apoptosis-inducing ligand receptor-1 (TRAIL-R1) gene and the susceptibility to b-cell non-hodgkin lymphoma (B-NHL) in Egypt.

Khorshied M et al.

Cancer Biomarkers : Section a of Disease Markers, 2021

Variants of genes encoding TNF receptors and ligands and proteins regulating TNF activation in familial multiple sclerosis.

Torre-Fuentes L et al.

Cns Neuroscience & Therapeutics, 2020

32951330 (PubMed )
Supplement: CNS-26-1178-s002.xlsx › Hoja1

The Impact of TRAIL (C1595T and G1525A) and DR4 (rs20576) Gene Polymorphisms on Systemic Lupus Erythematosus.

Sandoughi M et al.

Biochemical Genetics, 2020

Genetic variations in death receptor domain 4 gene and the susceptibility to hepatitis C related hepatocellular carcinoma.

Zayed SA et al.

Journal of Medical Virology, 2019

Evaluation of trail receptor 1 (DR4) polymorphisms C626G and A683C as risk factors of hepatocellular carcinoma.

Alsalawy NF et al.

Journal of Medical Virology, 2018

Characterization of Disease-Associated Mutations in Human Transmembrane Proteins.

Molnár J et al.

Plos One, 2016

26986070 (PubMed )
Supplement: pone.0151760.s001.xlsx › polymorphism

Death receptor 4 variants enhanced prostate cancer risk in North Indian population.

Mittal RD et al.

Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine, 2015

Identification of cancer predisposition variants in apparently healthy individuals using a next-generation sequencing-based family genomics approach.

Karageorgos I et al.

Human Genomics, 2015

26092435 (PubMed )
Supplement: 40246_2015_34_MOESM1_ESM.xlsx › FamilyA

Genetic polymorphisms and haplotypes of TRAIL gene correlate with NSCLC susceptibility in a group of Chinese patients.

Luo J et al.

International Journal of Clinical and Experimental Medicine, 2015

The eSNV-detect: a computational system to identify expressed single nucleotide variants from transcriptome sequencing data.

Tang X et al.

Nucleic Acids Research, 2014

25352556 (PubMed )
Supplement: supp_gku1005_nar-01266-met-n-2014-File012.xlsx › TCGA-A2-A04Y-01A.domain

Association of four polymorphisms in the death receptor 4 gene with cancer risk: an updated meta-analysis.

Lu J et al.

Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine, 2014

Association of polymorphisms in TRAIL1 and TRAILR1 genes with susceptibility to lymphomas.

Heredia-Galvez B et al.

Annals of Hematology, 2014

Death receptor (DR4) haplotypes are associated with increased susceptibility of gallbladder carcinoma in north Indian population.

Rai R et al.

Plos One, 2014

TRAIL-R1 is a negative regulator of pro-inflammatory responses and modulates long-term sequelae resulting from Chlamydia trachomatis infections in humans.

Al-Kuhlani M et al.

Plos One, 2014

Association of DR4 (TRAIL-R1) polymorphisms with cancer risk in Caucasians: an updated meta-analysis.

Chen W et al.

Asian Pacific Journal of Cancer Prevention : Apjcp, 2014

Association between laryngeal squamous cell carcinoma and polymorphisms in tumor necrosis factor related apoptosis induce ligand (TRAIL), TRAIL receptor and sTRAIL levels.

Verim A et al.

Asian Pacific Journal of Cancer Prevention : Apjcp, 2014

There is no significant association between death receptor 4 (DR4) gene polymorphisms and lung cancer in Turkish population.

Taştemir-Korkmaz D et al.

Pathology Oncology Research : Por, 2013

A Study of the Impact of Death Receptor 4 (DR4) Gene Polymorphisms in Alzheimer's Disease.

Edgünlü TG et al.

Balkan Medical Journal, 2013

Candidate gene study of TRAIL and TRAIL receptors: association with response to interferon beta therapy in multiple sclerosis patients.

López-Gómez C et al.

Plos One, 2013

Association of death receptor 4 variant (683A > C) with ovarian cancer risk in BRCA1 mutation carriers.

Dick MG et al.

International Journal of Cancer, 2012

TRAIL receptor I (DR4) polymorphisms C626G and A683C are associated with an increased risk for hepatocellular carcinoma (HCC) in HCV-infected patients.

Körner C et al.

Bmc Cancer, 2012

TRAIL-R1 polymorphisms and cancer susceptibility: an evidence-based meta-analysis.

Chen B et al.

European Journal of Cancer (oxford, England : 1990), 2009

Genetic variants in the death receptor 4 gene contribute to susceptibility to bladder cancer.

Wang M et al.

Mutation Research, 2009

TRAIL resistance of breast cancer cells is associated with constitutive endocytosis of death receptors 4 and 5.

Zhang Y et al.

Molecular Cancer Research : Mcr, 2008

Metastatic susceptibility locus, an 8p hot-spot for tumour progression disrupted in colorectal liver metastases: 13 candidate genes examined at the DNA, mRNA and protein level.

Macartney-Coxson DP et al.

Bmc Cancer, 2008

The Glu228Ala polymorphism in the ligand-binding domain of death receptor 4 is not associated with rheumatoid arthritis.

Yazdani-Biuki B et al.

Annals of the Rheumatic Diseases, 2008

The Glu228Ala polymorphism in the ligand binding domain of death receptor 4 is associated with increased risk for prostate cancer metastases.

Langsenlehner T et al.

The Prostate, 2008

Death receptor 4 variants and colorectal cancer risk.

Frank B et al.

Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology, 2006

Ala228 variant of trail receptor 1 affecting the ligand binding site is associated with chronic lymphocytic leukemia, mantle cell lymphoma, prostate cancer, head and neck squamous cell carcinoma and bladder cancer.

Wolf S et al.

International Journal of Cancer, 2006

Association of death receptor 4 haplotype 626C-683C with an increased breast cancer risk.

Frank B et al.

Carcinogenesis, 2005

Mutation analysis of the apoptotic "death-receptors" and the adaptors TRADD and FADD/MORT-1 in osteosarcoma tumor samples and osteosarcoma cell lines.

Dechant MJ et al.

International Journal of Cancer, 2004

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."