Varaico: Literature-Extracted Genetic Variants

Gene:TNIK
Variant:p.K54R
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TNIK

NM_015028.4:p.K54R

Associated Papers

Screens in aging-relevant human ALS-motor neurons identify MAP4Ks as therapeutic targets for the disease.

Liu ML et al.

Cell Death & Disease, 2024

Mutations in the postsynaptic density signaling hub TNIK disrupt PSD signaling in human models of neurodevelopmental disorders.

Jiang J et al.

Frontiers in Molecular Neuroscience, 2024

Chemical screens in aging-relevant human motor neurons identify MAP4Ks as therapeutic targets for amyotrophic lateral sclerosis.

Liu ML et al.

Biorxiv : the Preprint Server for Biology, 2023

Targeting of δ-catenin to postsynaptic sites through interaction with the Shank3 N-terminus.

Hassani Nia F et al.

Molecular Autism, 2020

33115499 (PubMed )
Supplement: 13229_2020_385_MOESM1_ESM.pdf

TDP-43 and NOVA-1 RNA-binding proteins as competitive splicing regulators of the schizophrenia-associated TNIK gene.

Gumina V et al.

Biochimica Et Biophysica Acta. Gene Regulatory Mechanisms, 2019

Identification of Phosphorylation Consensus Sequences and Endogenous Neuronal Substrates of the Psychiatric Risk Kinase TNIK.

Wang Q et al.

The Journal of Pharmacology and Experimental Therapeutics, 2016

The germinal center kinase TNIK is required for canonical NF-κB and JNK signaling in B-cells by the EBV oncoprotein LMP1 and the CD40 receptor.

Shkoda A et al.

Plos Biology, 2012

Agonistic and antagonistic roles for TNIK and MINK in non-canonical and canonical Wnt signalling.

Mikryukov A et al.

Plos One, 2012

The psychiatric disease risk factors DISC1 and TNIK interact to regulate synapse composition and function.

Wang Q et al.

Molecular Psychiatry, 2011

Traf2- and Nck-interacting kinase is essential for canonical Wnt signaling in Xenopus axis formation.

Satow R et al.

The Journal of Biological Chemistry, 2010

Regulation of Rap2A by the ubiquitin ligase Nedd4-1 controls neurite development.

Kawabe H et al.

Neuron, 2010

Identification of residues which regulate activity of the STE20-related kinase hMINK.

Lim J et al.

Biochemical and Biophysical Research Communications, 2003

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."