Associated Papers
Simultaneous enhancement of multiple functional properties using evolution-informed protein design.
Fram B et al.
Nature Communications, 2024
Experimental and In Silico Analysis of TEM β-Lactamase Adaptive Evolution.
Standley M et al.
Acs Infectious Diseases, 2022
36377311 (PubMed )
Supplement: id2c00216_si_005.xlsx › nodup
Assessment of Phenotype Relevant Amino Acid Residues in TEM-β-Lactamases by Mathematical Modelling and Experimental Approval.
Madzgalla S et al.
Microorganisms, 2021
Mutation supply and the repeatability of selection for antibiotic resistance.
van Dijk T et al.
Physical Biology, 2017
Network Analysis of Sequence-Function Relationships and Exploration of Sequence Space of TEM β-Lactamases.
Zeil C et al.
Antimicrobial Agents and Chemotherapy, 2016
TRINS: a method for gene modification by randomized tandem repeat insertions.
Kipnis Y et al.
Protein Engineering, Design & Selection : Peds, 2012
High tolerance to simultaneous active-site mutations in TEM-1 beta-lactamase: Distinct mutational paths provide more generalized beta-lactam recognition.
De Wals PY et al.
Protein Science : a Publication of the Protein Society, 2009
Site-directed mutagenesis of beta-lactamase TEM-1. Investigating the potential role of specific residues on the activity of Pseudomonas-specific enzymes.
Lenfant F et al.
European Journal of Biochemistry, 1993
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