Associated Papers
Experimental Models of Hypertrophic Cardiomyopathy: A Systematic Review.
van den Dolder FW et al.
Jacc. Basic to Translational Science, 2025
Exosomally derived Y RNA fragment alleviates hypertrophic cardiomyopathy in transgenic mice.
Huang F et al.
Molecular Therapy. Nucleic Acids, 2021
Cardiomyopathic troponin mutations predominantly occur at its interface with actin and tropomyosin.
Tobacman LS et al.
The Journal of General Physiology, 2021
Restrictive Cardiomyopathy Troponin I R145W Mutation Does Not Perturb Myofilament Length-dependent Activation in Human Cardiac Sarcomeres.
Dvornikov AV et al.
The Journal of Biological Chemistry, 2016
Effects of Cardiac Troponin I Mutation P83S on Contractile Properties and the Modulation by PKA-Mediated Phosphorylation.
Cheng Y et al.
The Journal of Physical Chemistry. B, 2016
The Cardiomyopathy Mutation, R146G Troponin I, Stabilizes the Intermediate "C" State of Regulated Actin under High- and Low-Free Ca(2+) Conditions.
Johnson D et al.
Biochemistry, 2016
Troponins, intrinsic disorder, and cardiomyopathy.
Na I et al.
Biological Chemistry, 2016
Cardiac troponin structure-function and the influence of hypertrophic cardiomyopathy associated mutations on modulation of contractility.
Cheng Y et al.
Archives of Biochemistry and Biophysics, 2016
Cardiac Troponin and Tropomyosin: Structural and Cellular Perspectives to Unveil the Hypertrophic Cardiomyopathy Phenotype.
Marques MA et al.
Frontiers in Physiology, 2016
Troponin I Mutations R146G and R21C Alter Cardiac Troponin Function, Contractile Properties, and Modulation by Protein Kinase A (PKA)-mediated Phosphorylation.
Cheng Y et al.
The Journal of Biological Chemistry, 2015
The myosin-activated thin filament regulatory state, M⁻-open: a link to hypertrophic cardiomyopathy (HCM).
Lehrer SS et al.
Journal of Muscle Research and Cell Motility, 2014
Structural and kinetic effects of hypertrophic cardiomyopathy related mutations R146G/Q and R163W on the regulatory switching activity of rat cardiac troponin I.
Zhou Z et al.
Archives of Biochemistry and Biophysics, 2013
Inherited cardiomyopathies caused by troponin mutations.
Lu QW et al.
Journal of Geriatric Cardiology : Jgc, 2013
Integration of troponin I phosphorylation with cardiac regulatory networks.
Solaro RJ et al.
Circulation Research, 2013
Combinatorial effects of double cardiomyopathy mutant alleles in rodent myocytes: a predictive cellular model of myofilament dysregulation in disease.
Davis J et al.
Plos One, 2010
Role of animal models in HCM research.
Shephard R et al.
Journal of Cardiovascular Translational Research, 2009
Ala scanning of the inhibitory region of cardiac troponin I.
Kobayashi T et al.
The Journal of Biological Chemistry, 2009
Some cardiomyopathy-causing troponin I mutations stabilize a functional intermediate actin state.
Mathur MC et al.
Biophysical Journal, 2009
Tyrosine phosphorylation modifies protein kinase C delta-dependent phosphorylation of cardiac troponin I.
Sumandea MP et al.
The Journal of Biological Chemistry, 2008
Functional consequences of the human cardiac troponin I hypertrophic cardiomyopathy mutation R145G in transgenic mice.
Wen Y et al.
The Journal of Biological Chemistry, 2008
Allele and species dependent contractile defects by restrictive and hypertrophic cardiomyopathy-linked troponin I mutants.
Davis J et al.
Journal of Molecular and Cellular Cardiology, 2008
Lys184 deletion in troponin I impairs relaxation kinetics and induces hypercontractility in murine cardiac myofibrils.
Iorga B et al.
Cardiovascular Research, 2008
Use of 2-D DIGE analysis reveals altered phosphorylation in a tropomyosin mutant (Glu54Lys) linked to dilated cardiomyopathy.
Warren CM et al.
Proteomics, 2008
Phosphorylation-dependent conformational transition of the cardiac specific N-extension of troponin I in cardiac troponin.
Howarth JW et al.
Journal of Molecular Biology, 2007
Thin filament disinhibition by restrictive cardiomyopathy mutant R193H troponin I induces Ca2+-independent mechanical tone and acute myocyte remodeling.
Davis J et al.
Circulation Research, 2007
Molecular insights from a novel cardiac troponin I mouse model of familial hypertrophic cardiomyopathy.
Tsoutsman T et al.
Journal of Molecular and Cellular Cardiology, 2006
Increased Ca2+ affinity of cardiac thin filaments reconstituted with cardiomyopathy-related mutant cardiac troponin I.
Kobayashi T et al.
The Journal of Biological Chemistry, 2006
Transgenic rabbit model for human troponin I-based hypertrophic cardiomyopathy.
Sanbe A et al.
Circulation, 2005
Effects of the mutation R145G in human cardiac troponin I on the kinetics of the contraction-relaxation cycle in isolated cardiac myofibrils.
Kruger M et al.
The Journal of Physiology, 2005
Cellular and molecular aspects of familial hypertrophic cardiomyopathy caused by mutations in the cardiac troponin I gene.
Gomes AV et al.
Molecular and Cellular Biochemistry, 2004
Effects of protein kinase C dependent phosphorylation and a familial hypertrophic cardiomyopathy-related mutation of cardiac troponin I on structural transition of troponin C and myofilament activation.
Kobayashi T et al.
Biochemistry, 2004
Calpain-1-dependent degradation of troponin I mutants found in familial hypertrophic cardiomyopathy.
Barta J et al.
Molecular and Cellular Biochemistry, 2003
Myofilament calcium sensitivity and cardiac disease: insights from troponin I isoforms and mutants.
Westfall MV et al.
Circulation Research, 2002
Ca(2+)-desensitizing effect of a deletion mutation Delta K210 in cardiac troponin T that causes familial dilated cardiomyopathy.
Morimoto S et al.
Proceedings of the National Academy of Sciences of the United States of America, 2002
Transgenic modeling of a cardiac troponin I mutation linked to familial hypertrophic cardiomyopathy.
James J et al.
Circulation Research, 2000