Varaico: Literature-Extracted Genetic Variants

Gene:TOP1
Variant:p.F361S
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TOP1

NM_003286.4:p.F361S

Associated Papers

Mechanism of action of non-camptothecin inhibitor Genz-644282 in topoisomerase I inhibition.

Nishida M et al.

Communications Biology, 2022

New Topoisomerase I mutations are associated with resistance to camptothecin.

Gongora C et al.

Molecular Cancer, 2011

Topoisomerase I gene mutations at F270 in the large subunit and N184 in the small subunit contribute to the resistance mechanism of the unicellular parasite Leishmania donovani towards 3,3'-diindolylmethane.

Roy A et al.

Antimicrobial Agents and Chemotherapy, 2009

Effects of drug efflux proteins and topoisomerase I mutations on the camptothecin analogue gimatecan.

Gounder MK et al.

Investigational New Drugs, 2008

SR proteins as potential targets for therapy.

Soret J et al.

Progress in Molecular and Subcellular Biology, 2006

Effects of mutations in the F361 to R364 region of topoisomerase I (Topo I), in the presence and absence of 9-aminocamptothecin, on the Topo I-DNA interaction.

Pond CD et al.

Anti-cancer Drugs, 1999

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."