Associated Papers
TOP1 Mutations and Cross-Resistance to Antibody-Drug Conjugates in Patients with Metastatic Breast Cancer.
Abelman RO et al.
Clinical Cancer Research : an Official Journal of the American Association for Cancer Research, 2025
Mechanism of action of non-camptothecin inhibitor Genz-644282 in topoisomerase I inhibition.
Nishida M et al.
Communications Biology, 2022
Characterization of DNA topoisomerase I in three SN-38 resistant human colon cancer cell lines reveals a new pair of resistance-associated mutations.
Jensen NF et al.
Journal of Experimental & Clinical Cancer Research : Cr, 2016
Molecular and cellular pharmacology of the novel noncamptothecin topoisomerase I inhibitor Genz-644282.
Sooryakumar D et al.
Molecular Cancer Therapeutics, 2011
New Topoisomerase I mutations are associated with resistance to camptothecin.
Gongora C et al.
Molecular Cancer, 2011
Topoisomerase I gene mutations at F270 in the large subunit and N184 in the small subunit contribute to the resistance mechanism of the unicellular parasite Leishmania donovani towards 3,3'-diindolylmethane.
Roy A et al.
Antimicrobial Agents and Chemotherapy, 2009
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