Associated Papers
Mechanism of action of non-camptothecin inhibitor Genz-644282 in topoisomerase I inhibition.
Nishida M et al.
Communications Biology, 2022
The human DNA topoisomerase I mutant Gly717Asp: Higher religation rate is not always associated with camptothecin resistance.
Wang Z et al.
Archives of Biochemistry and Biophysics, 2019
New Topoisomerase I mutations are associated with resistance to camptothecin.
Gongora C et al.
Molecular Cancer, 2011
Topoisomerase I gene mutations at F270 in the large subunit and N184 in the small subunit contribute to the resistance mechanism of the unicellular parasite Leishmania donovani towards 3,3'-diindolylmethane.
Roy A et al.
Antimicrobial Agents and Chemotherapy, 2009
A single mutation in the 729 residue modulates human DNA topoisomerase IB DNA binding and drug resistance.
Losasso C et al.
Nucleic Acids Research, 2008
Alterations in linker flexibility suppress DNA topoisomerase I mutant-induced cell lethality.
Losasso C et al.
The Journal of Biological Chemistry, 2007
Single mutation in the linker domain confers protein flexibility and camptothecin resistance to human topoisomerase I.
Fiorani P et al.
The Journal of Biological Chemistry, 2003
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