Varaico: Literature-Extracted Genetic Variants

Gene:TOP1
Variant:p.V703I
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TOP1

NM_003286.4:p.V703I

Associated Papers

The human DNA topoisomerase I mutant Gly717Asp: Higher religation rate is not always associated with camptothecin resistance.

Wang Z et al.

Archives of Biochemistry and Biophysics, 2019

DNA topoisomerase I domain interactions impact enzyme activity and sensitivity to camptothecin.

Wright CM et al.

The Journal of Biological Chemistry, 2015

Directed evolution to increase camptothecin sensitivity of human DNA topoisomerase I.

Scaldaferro S et al.

Chemistry & Biology, 2001

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."