Varaico: Literature-Extracted Genetic Variants

Gene:TOP1
Variant:p.E710G
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TOP1

NM_003286.4:p.E710G

Associated Papers

Mechanism of action of non-camptothecin inhibitor Genz-644282 in topoisomerase I inhibition.

Nishida M et al.

Communications Biology, 2022

The human DNA topoisomerase I mutant Gly717Asp: Higher religation rate is not always associated with camptothecin resistance.

Wang Z et al.

Archives of Biochemistry and Biophysics, 2019

Characterization of DNA topoisomerase I in three SN-38 resistant human colon cancer cell lines reveals a new pair of resistance-associated mutations.

Jensen NF et al.

Journal of Experimental & Clinical Cancer Research : Cr, 2016

New Topoisomerase I mutations are associated with resistance to camptothecin.

Gongora C et al.

Molecular Cancer, 2011

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."