Varaico: Literature-Extracted Genetic Variants

Gene:TOP1
Variant:p.T718A
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TOP1

NM_003286.4:p.T718A

Associated Papers

Replication-associated formation and repair of human topoisomerase IIIα cleavage complexes.

Saha LK et al.

Nature Communications, 2023

37024461 (PubMed )
Supplement: 41467_2023_37498_MOESM1_ESM.pdf

Topoisomerase 1 Regulates Gene Expression in Neurons through Cleavage Complex-Dependent and -Independent Mechanisms.

Mabb AM et al.

Plos One, 2016

A single mutation in the 729 residue modulates human DNA topoisomerase IB DNA binding and drug resistance.

Losasso C et al.

Nucleic Acids Research, 2008

Alterations in linker flexibility suppress DNA topoisomerase I mutant-induced cell lethality.

Losasso C et al.

The Journal of Biological Chemistry, 2007

The different cleavage DNA sequence specificity explains the camptothecin resistance of the human topoisomerase I Glu418Lys mutant.

Fiorani P et al.

Nucleic Acids Research, 2006

Effect on DNA relaxation of the single Thr718Ala mutation in human topoisomerase I: a functional and molecular dynamics study.

Chillemi G et al.

Nucleic Acids Research, 2005

Domain interactions affecting human DNA topoisomerase I catalysis and camptothecin sensitivity.

Fiorani P et al.

Molecular Pharmacology, 1999

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."