Varaico: Literature-Extracted Genetic Variants

Gene:TOP1
Variant:p.N722S
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TOP1

NM_003286.4:p.N722S

Associated Papers

Mechanism of action of non-camptothecin inhibitor Genz-644282 in topoisomerase I inhibition.

Nishida M et al.

Communications Biology, 2022

Molecular and cellular pharmacology of the novel noncamptothecin topoisomerase I inhibitor Genz-644282.

Sooryakumar D et al.

Molecular Cancer Therapeutics, 2011

New Topoisomerase I mutations are associated with resistance to camptothecin.

Gongora C et al.

Molecular Cancer, 2011

Identification of gene polymorphisms of human DNA topoisomerase I in the National Cancer Institute panel of human tumour cell lines.

Moisan F et al.

British Journal of Cancer, 2006

Substitution of conserved residues within the active site alters the cleavage religation equilibrium of DNA topoisomerase I.

Colley WC et al.

The Journal of Biological Chemistry, 2004

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."