Varaico: Literature-Extracted Genetic Variants

Gene:TOP2A
Variant:p.Y805F
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TOP2A

NM_001067.4:p.Y805F

Associated Papers

The abscission checkpoint senses chromatin bridges through Top2α recruitment to DNA knots.

Petsalaki E et al.

The Journal of Cell Biology, 2023

37638884 (PubMed )
Supplement: JCB_202303123_review_history.pdf

Recurrent mutations in topoisomerase IIα cause a previously undescribed mutator phenotype in human cancers.

Boot A et al.

Proceedings of the National Academy of Sciences of the United States of America, 2022

A mutation in human topoisomerase II alpha whose expression is lethal in DNA repair-deficient yeast cells.

Walker JV et al.

The Journal of Biological Chemistry, 2004

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."