Varaico: Literature-Extracted Genetic Variants

Gene:TOP2A
Variant:p.R162Q
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TOP2A

NM_001067.4:p.R162Q

Associated Papers

A comprehensive structural analysis of the ATPase domain of human DNA topoisomerase II beta bound to AMPPNP, ADP, and the bisdioxopiperazine, ICRF193.

Ling EM et al.

Structure (london, England : 1993), 2022

Topoisomerase IIalpha controls the decatenation checkpoint.

Luo K et al.

Nature Cell Biology, 2009

Human small cell lung cancer NYH cells selected for resistance to the bisdioxopiperazine topoisomerase II catalytic inhibitor ICRF-187 demonstrate a functional R162Q mutation in the Walker A consensus ATP binding domain of the alpha isoform.

Wessel I et al.

Cancer Research, 1999

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."