Varaico: Literature-Extracted Genetic Variants

Gene:TOP2A
Variant:p.Y50F
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TOP2A

NM_001067.4:p.Y50F

Associated Papers

A comprehensive structural analysis of the ATPase domain of human DNA topoisomerase II beta bound to AMPPNP, ADP, and the bisdioxopiperazine, ICRF193.

Ling EM et al.

Structure (london, England : 1993), 2022

Stability of the topoisomerase II closed clamp conformation may influence DNA-stimulated ATP hydrolysis.

Vaughn J et al.

The Journal of Biological Chemistry, 2005

A mutation in human topoisomerase II alpha whose expression is lethal in DNA repair-deficient yeast cells.

Walker JV et al.

The Journal of Biological Chemistry, 2004

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."