Associated Papers
Cytosolic TOP3α facilitates mitochondrial DNA sensing by cGAS.
Cai D et al.
Embo Reports, 2025
Pathogenic variants in human DNA damage repair genes mostly arose after the latest human out-of-Africa migration.
He J et al.
Frontiers in Genetics, 2024
38948361 (PubMed )
Supplement: Table1.XLSX › Sheet1
Pathological variants in TOP3A cause distinct disorders of mitochondrial and nuclear genome stability.
Erdinc D et al.
Embo Molecular Medicine, 2023
Mitochondrial Cardiomyopathy: Molecular Epidemiology, Diagnosis, Models, and Therapeutic Management.
Yang J et al.
Cells, 2022
Distinct landscapes of deleterious variants in DNA damage repair system in ethnic human populations.
Qin Z et al.
Life Science Alliance, 2022
35595529 (PubMed )
Supplement: LSA-2021-01319_TableS3.xlsx › S3F
Novel TOP3A Variant Associated With Mitochondrial Disease: Expanding the Clinical Spectrum of Topoisomerase III Alpha-Related Diseases.
Primiano G et al.
Neurology. Genetics, 2022
Mutations in TOP3A Cause a Bloom Syndrome-like Disorder.
Martin CA et al.
American Journal of Human Genetics, 2018
Topoisomerase 3α Is Required for Decatenation and Segregation of Human mtDNA.
Nicholls TJ et al.
Molecular Cell, 2018
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