Varaico: Literature-Extracted Genetic Variants

Gene:TOPBP1
Variant:p.W1145R
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TOPBP1

NM_007027.4:p.W1145R

Associated Papers

Decoding Missense Variants by Incorporating Phase Separation via Machine Learning.

Feng M et al.

Nature Communications, 2024

39333476 (PubMed )
Supplement: 41467_2024_52580_MOESM4_ESM.xlsx › impact_ps_mutations

Treacle controls the nucleolar response to rDNA breaks via TOPBP1 recruitment and ATR activation.

Mooser C et al.

Nature Communications, 2020

RPA-Binding Protein ETAA1 Is an ATR Activator Involved in DNA Replication Stress Response.

Lee YC et al.

Current Biology : Cb, 2016

Activation of the ATR kinase by the RPA-binding protein ETAA1.

Haahr P et al.

Nature Cell Biology, 2016

Direct role for the replication protein treslin (Ticrr) in the ATR kinase-mediated checkpoint response.

Hassan BH et al.

The Journal of Biological Chemistry, 2013

The Rad9-Hus1-Rad1 (9-1-1) clamp activates checkpoint signaling via TopBP1.

Delacroix S et al.

Genes & Development, 2007

TopBP1 activates the ATR-ATRIP complex.

Kumagai A et al.

Cell, 2006

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."