Associated Papers
The p53 R181C mutation accumulates through impaired deacetylation by Sirt1 and facilitates tumor development.
Wang E et al.
Communications Biology, 2026
TP53 variant clusters stratify phenotypic diversity in germline carriers and reveal an osteosarcoma-prone subgroup.
Fischer NW et al.
Nature Communications, 2025
Unraveling the unique amyloid-like aggregation behavior of the tumor suppressor p53 mutants in human cancers.
Manav N et al.
International Journal of Biological Macromolecules, 2025
Alternatively mechanistic insights into acetylation in p53-mediated transcriptional regulation of cancer cell-intrinsic PD-1.
Wen J et al.
Fundamental Research, 2023
Targeting KRAS-mutant stomach/colorectal tumors by disrupting the ERK2-p53 complex.
Wang X et al.
Cell Reports, 2023
Transcription-independent functions of p53 in DNA repair pathway selection.
Wang YH et al.
Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology, 2023
TP53_PROF: a machine learning model to predict impact of missense mutations in TP53.
Ben-Cohen G et al.
Briefings in Bioinformatics, 2022
Analysis of single-nucleotide polymorphisms in genes associated with triple-negative breast cancer.
G V et al.
Frontiers in Genetics, 2022
Targeted sequencing of FH-deficient uterine leiomyomas reveals biallelic inactivating somatic fumarase variants and allows characterization of missense variants.
Popp B et al.
Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc, 2020
PBRM1 acts as a p53 lysine-acetylation reader to suppress renal tumor growth.
Cai W et al.
Nature Communications, 2019
Temporal and differential regulation of KAISO-controlled transcription by phosphorylated and acetylated p53 highlights a crucial regulatory role of apoptosis.
Choi SH et al.
The Journal of Biological Chemistry, 2019
Live-cell p53 single-molecule binding is modulated by C-terminal acetylation and correlates with transcriptional activity.
Loffreda A et al.
Nature Communications, 2017
The p53 C terminus controls site-specific DNA binding and promotes structural changes within the central DNA binding domain.
Laptenko O et al.
Molecular Cell, 2015
The nucleolar protein Myb-binding protein 1A (MYBBP1A) enhances p53 tetramerization and acetylation in response to nucleolar disruption.
Ono W et al.
The Journal of Biological Chemistry, 2014
Monocytic leukemia zinc finger (MOZ) interacts with p53 to induce p21 expression and cell-cycle arrest.
Rokudai S et al.
The Journal of Biological Chemistry, 2009
Identification and characterization of a novel p300-mediated p53 acetylation site, lysine 305.
Wang YH et al.
The Journal of Biological Chemistry, 2003