Varaico: Literature-Extracted Genetic Variants

Gene:TP53
Variant:p.S378A
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TP53

NM_000546.6:p.S378A

Associated Papers

Deciphering the acetylation code of p53 in transcription regulation and tumor suppression.

Xia Z et al.

Oncogene, 2022

TP53_PROF: a machine learning model to predict impact of missense mutations in TP53.

Ben-Cohen G et al.

Briefings in Bioinformatics, 2022

35043155 (PubMed )
Supplement: supplementary_table_s1_bbab524.xlsx › S1B._Negative_Set

Regulation of p53 by the 14-3-3 protein interaction network: new opportunities for drug discovery in cancer.

Falcicchio M et al.

Cell Death Discovery, 2020

Downregulation of the DNA Repair Gene DDB2 by Arecoline Is through p53's DNA-Binding Domain and Is Correlated with Poor Outcome of Head and Neck Cancer Patients with Betel Quid Consumption.

Wang YC et al.

Cancers, 2020

Finding driver mutations in cancer: Elucidating the role of background mutational processes.

Brown AL et al.

Plos Computational Biology, 2019

31034466 (PubMed )
Supplement: pcbi.1006981.s010.xlsx › final_benchmark

SMG7 is a critical regulator of p53 stability and function in DNA damage stress response.

Luo H et al.

Cell Discovery, 2016

27462439 (PubMed )
Supplement: celldisc201542-s2.pdf

p53 Acetylation: Regulation and Consequences.

Reed SM et al.

Cancers, 2014

Nuclear export regulation of COP1 by 14-3-3σ in response to DNA damage.

Su CH et al.

Molecular Cancer, 2010

Mechanistic differences in the transcriptional activation of p53 by 14-3-3 isoforms.

Rajagopalan S et al.

Nucleic Acids Research, 2010

Activation of NFAT signal by p53-K120R mutant.

Shinmen N et al.

Febs Letters, 2009

Phosphorylation at carboxyl-terminal S373 and S375 residues and 14-3-3 binding are not required for mouse p53 function.

Lee MK et al.

Neoplasia (new York, N.y.), 2007

Role of phosphorylation in p53 acetylation and PAb421 epitope recognition in baculoviral and mammalian expressed proteins.

Warnock LJ et al.

The Febs Journal, 2005

The interaction of p53 with the nuclear matrix is mediated by F-actin and modulated by DNA damage.

Okorokov AL et al.

Oncogene, 2002

ATM-dependent activation of p53 involves dephosphorylation and association with 14-3-3 proteins.

Waterman MJ et al.

Nature Genetics, 1998

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."