Varaico: Literature-Extracted Genetic Variants

Gene:TP53
Variant:p.K373Q
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TP53

NM_000546.6:p.K373Q

Associated Papers

TP53 variant clusters stratify phenotypic diversity in germline carriers and reveal an osteosarcoma-prone subgroup.

Fischer NW et al.

Nature Communications, 2025

41022739 (PubMed )
Supplement: 41467_2025_63528_MOESM7_ESM.xlsx › Sheet1

Unraveling the unique amyloid-like aggregation behavior of the tumor suppressor p53 mutants in human cancers.

Manav N et al.

International Journal of Biological Macromolecules, 2025

Alternatively mechanistic insights into acetylation in p53-mediated transcriptional regulation of cancer cell-intrinsic PD-1.

Wen J et al.

Fundamental Research, 2023

Transcription-independent functions of p53 in DNA repair pathway selection.

Wang YH et al.

Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology, 2023

TP53_PROF: a machine learning model to predict impact of missense mutations in TP53.

Ben-Cohen G et al.

Briefings in Bioinformatics, 2022

35043155 (PubMed )
Supplement: supplementary_table_s1_bbab524.xlsx › S1B._Negative_Set

Targeted sequencing of FH-deficient uterine leiomyomas reveals biallelic inactivating somatic fumarase variants and allows characterization of missense variants.

Popp B et al.

Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc, 2020

32612247 (PubMed )
Supplement: 41379_2020_596_MOESM2_ESM.xlsx › allFH_missense

ID4 regulates transcriptional activity of wild type and mutant p53 via K373 acetylation.

Morton DJ et al.

Oncotarget, 2017

The p53 C terminus controls site-specific DNA binding and promotes structural changes within the central DNA binding domain.

Laptenko O et al.

Molecular Cell, 2015

The nucleolar protein Myb-binding protein 1A (MYBBP1A) enhances p53 tetramerization and acetylation in response to nucleolar disruption.

Ono W et al.

The Journal of Biological Chemistry, 2014

Kinetics of repression by modified p53 on the PDGF beta-receptor promoter.

Yang W et al.

International Journal of Cancer, 2008

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."