Associated Papers
TP53 variant clusters stratify phenotypic diversity in germline carriers and reveal an osteosarcoma-prone subgroup.
Fischer NW et al.
Nature Communications, 2025
Cabozantinib selectively induces proteasomal degradation of p53 somatic mutant Y220C and impedes tumor growth.
Lv FL et al.
The Journal of Biological Chemistry, 2025
Deciphering the acetylation code of p53 in transcription regulation and tumor suppression.
Xia Z et al.
Oncogene, 2022
TP53_PROF: a machine learning model to predict impact of missense mutations in TP53.
Ben-Cohen G et al.
Briefings in Bioinformatics, 2022
IKKα mediates UVB-induced cell apoptosis by regulating p53 pathway activation.
Wang H et al.
Ecotoxicology and Environmental Safety, 2021
Dysfunction of X-linked inhibitor of apoptosis protein (XIAP) triggers neuropathological processes via altered p53 activity in Huntington's disease.
Hyeon SJ et al.
Progress in Neurobiology, 2021
mTOR inhibition acts as an unexpected checkpoint in p53-mediated tumor suppression.
Kon N et al.
Genes & Development, 2021
Insights into the limitations of transient expression systems for the functional study of p53 acetylation site and oncogenic mutants.
Bruer M et al.
Biochemical and Biophysical Research Communications, 2020
p53 β-hydroxybutyrylation attenuates p53 activity.
Liu K et al.
Cell Death & Disease, 2019
USP15-dependent lysosomal pathway controls p53-R175H turnover in ovarian cancer cells.
Padmanabhan A et al.
Nature Communications, 2018
Inhibiting p53 Acetylation Reduces Cancer Chemotoxicity.
Zheng S et al.
Cancer Research, 2017
The p53 C terminus controls site-specific DNA binding and promotes structural changes within the central DNA binding domain.
Laptenko O et al.
Molecular Cell, 2015
p53 degradation by a coronavirus papain-like protease suppresses type I interferon signaling.
Yuan L et al.
The Journal of Biological Chemistry, 2015
Mutant TP53 posttranslational modifications: challenges and opportunities.
Nguyen TA et al.
Human Mutation, 2014
Insights into wild-type and mutant p53 functions provided by genetically engineered mice.
Donehower LA
Human Mutation, 2014
Illuminating p53 function in cancer with genetically engineered mouse models.
Garcia PB et al.
Seminars in Cell & Developmental Biology, 2014
The nucleolar protein Myb-binding protein 1A (MYBBP1A) enhances p53 tetramerization and acetylation in response to nucleolar disruption.
Ono W et al.
The Journal of Biological Chemistry, 2014
PIASy-mediated Tip60 sumoylation regulates p53-induced autophagy.
Naidu SR et al.
Cell Cycle (georgetown, Tex.), 2012
p85α mediates p53 K370 acetylation by p300 and regulates its promoter-specific transactivity in the cellular UVB response.
Song L et al.
Oncogene, 2011
p53 stabilization and transactivation by a von Hippel-Lindau protein.
Roe JS et al.
Molecular Cell, 2006
Mdm2-mediated NEDD8 conjugation of p53 inhibits its transcriptional activity.
Xirodimas DP et al.
Cell, 2004