Associated Papers
Phosphoproteomics of primary AML patient samples reveals rationale for AKT combination therapy and p53 context to overcome selinexor resistance.
Emdal KB et al.
Cell Reports, 2022
TP53_PROF: a machine learning model to predict impact of missense mutations in TP53.
Ben-Cohen G et al.
Briefings in Bioinformatics, 2022
Multiple biochemical properties of the p53 molecule contribute to activation of polymerase iota-dependent DNA damage tolerance.
Biber S et al.
Nucleic Acids Research, 2020
Downregulation of the DNA Repair Gene DDB2 by Arecoline Is through p53's DNA-Binding Domain and Is Correlated with Poor Outcome of Head and Neck Cancer Patients with Betel Quid Consumption.
Wang YC et al.
Cancers, 2020
How the Other Half Lives: What p53 Does When It Is Not Being a Transcription Factor.
Ho T et al.
International Journal of Molecular Sciences, 2019
Finding driver mutations in cancer: Elucidating the role of background mutational processes.
Brown AL et al.
Plos Computational Biology, 2019
p53: emerging roles in stem cells, development and beyond.
Jain AK et al.
Development (cambridge, England), 2018
Mutant p53 promotes tumor cell malignancy by both positive and negative regulation of the transforming growth factor β (TGF-β) pathway.
Ji L et al.
The Journal of Biological Chemistry, 2015
EBNA3C regulates p53 through induction of Aurora kinase B.
Jha HC et al.
Oncotarget, 2015
Phosphoproteome dynamics in onset and maintenance of oncogene-induced senescence.
de Graaf EL et al.
Molecular & Cellular Proteomics : Mcp, 2014
Mutant TP53 posttranslational modifications: challenges and opportunities.
Nguyen TA et al.
Human Mutation, 2014
Insights into wild-type and mutant p53 functions provided by genetically engineered mice.
Donehower LA
Human Mutation, 2014
A novel Aurora-A-mediated phosphorylation of p53 inhibits its interaction with MDM2.
Hsueh KW et al.
Biochimica Et Biophysica Acta, 2013
Kaposi's sarcoma herpesvirus upregulates Aurora A expression to promote p53 phosphorylation and ubiquitylation.
Cai Q et al.
Plos Pathogens, 2012
Functional significance of Aurora kinase A regulatory interactions with p53-ERα complex in human breast cancer cells.
Katayama H et al.
Hormones & Cancer, 2011
Serine 312 phosphorylation is dispensable for wild-type p53 functions in vivo.
Lee MK et al.
Cell Death and Differentiation, 2011
Cyclin B1/Cdk1 phosphorylation of mitochondrial p53 induces anti-apoptotic response.
Nantajit D et al.
Plos One, 2010
The eIF2alpha kinases PERK and PKR activate glycogen synthase kinase 3 to promote the proteasomal degradation of p53.
Baltzis D et al.
The Journal of Biological Chemistry, 2007
How important are post-translational modifications in p53 for selectivity in target-gene transcription and tumour suppression?
Olsson A et al.
Cell Death and Differentiation, 2007
Destabilizing missense mutations in the tumour suppressor protein p53 enhance its ubiquitination in vitro and in vivo.
Shimizu H et al.
The Biochemical Journal, 2006
The centrosome cycle.
Mattison CP et al.
Results and Problems in Cell Differentiation, 2006
Transcription-independent suppression of DNA synthesis by p53 in sperm-irradiated mouse zygotes.
Toyoshima M et al.
Oncogene, 2005
Role of phosphorylation in p53 acetylation and PAb421 epitope recognition in baculoviral and mammalian expressed proteins.
Warnock LJ et al.
The Febs Journal, 2005
Aurora-A abrogation of p53 DNA binding and transactivation activity by phosphorylation of serine 215.
Liu Q et al.
The Journal of Biological Chemistry, 2004
DNA-dependent protein kinase and checkpoint kinase 2 synergistically activate a latent population of p53 upon DNA damage.
Jack MT et al.
The Journal of Biological Chemistry, 2004
Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3beta.
Qu L et al.
Genes & Development, 2004
Phosphorylation by aurora kinase A induces Mdm2-mediated destabilization and inhibition of p53.
Katayama H et al.
Nature Genetics, 2004
The prolyl isomerase Pin1 reveals a mechanism to control p53 functions after genotoxic insults.
Zacchi P et al.
Nature, 2002
Difference in the centrosome duplication regulatory activity among p53 'hot spot' mutants: potential role of Ser 315 phosphorylation-dependent centrosome binding of p53.
Tarapore P et al.
Oncogene, 2001
DNA damage induced p53 stabilization: no indication for an involvement of p53 phosphorylation.
Blattner C et al.
Oncogene, 1999
Cooperation of a single lysine mutation and a C-terminal domain in the cytoplasmic sequestration of the p53 protein.
Liang SH et al.
The Journal of Biological Chemistry, 1998
Cdk2 kinase phosphorylates serine 315 of human p53 in vitro.
Price BD et al.
Oncogene, 1995