Associated Papers
TP53 variant clusters stratify phenotypic diversity in germline carriers and reveal an osteosarcoma-prone subgroup.
Fischer NW et al.
Nature Communications, 2025
Deep CRISPR mutagenesis characterizes the functional diversity of TP53 mutations.
Funk JS et al.
Nature Genetics, 2025
Scalable approaches for generating, validating and incorporating data from high-throughput functional assays to improve clinical variant classification.
Padigepati SR et al.
Human Genetics, 2024
A Small Molecule Reacts with the p53 Somatic Mutant Y220C to Rescue Wild-type Thermal Stability.
Guiley KZ et al.
Cancer Discovery, 2023
Circulating tumor DNA to guide rechallenge with panitumumab in metastatic colorectal cancer: the phase 2 CHRONOS trial.
Sartore-Bianchi A et al.
Nature Medicine, 2022
Comprehensive Identification of Deleterious TP53 Missense VUS Variants Based on Their Impact on TP53 Structural Stability.
Tam B et al.
International Journal of Molecular Sciences, 2021
p53 Forms Redox-Dependent Protein-Protein Interactions through Cysteine 277.
Shi T et al.
Antioxidants (basel, Switzerland), 2021
Pathogenic genetic variants from highly connected cancer susceptibility genes confer the loss of structural stability.
Reza MN et al.
Scientific Reports, 2021
DNA damage and oxidant stress activate p53 through differential upstream signaling pathways.
Shi T et al.
Free Radical Biology & Medicine, 2021
Finding driver mutations in cancer: Elucidating the role of background mutational processes.
Brown AL et al.
Plos Computational Biology, 2019
Contribution of allelic imbalance to colorectal cancer.
Palin K et al.
Nature Communications, 2018
The curcumin analog HO-3867 selectively kills cancer cells by converting mutant p53 protein to transcriptionally active wildtype p53.
Madan E et al.
The Journal of Biological Chemistry, 2018
Oxidation of p53 through DNA charge transport involves a network of disulfides within the DNA-binding domain.
Schaefer KN et al.
Biochemistry, 2015
Murine protein serine-threonine kinase 38 activates p53 function through Ser15 phosphorylation.
Seong HA et al.
The Journal of Biological Chemistry, 2012
Identification of two reactive cysteine residues in the tumor suppressor protein p53 using top-down FTICR mass spectrometry.
Scotcher J et al.
Journal of the American Society for Mass Spectrometry, 2011
TP53 mutation analysis of malignant peripheral nerve sheath tumors.
Verdijk RM et al.
Journal of Neuropathology and Experimental Neurology, 2010
Effect of thioredoxin deletion and p53 cysteine replacement on human p53 activity in wild-type and thioredoxin reductase null yeast.
Stoner CS et al.
Biochemistry, 2009
Redox state of tumor suppressor p53 regulates its sequence-specific DNA binding in DNA-damaged cells by cysteine 277.
Buzek J et al.
Nucleic Acids Research, 2002
In vitro evolution of thermostable p53 variants.
Matsumura I et al.
Protein Science : a Publication of the Protein Society, 1999