Varaico: Literature-Extracted Genetic Variants

Gene:TP53
Variant:p.Y220F
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TP53

NM_000546.6:p.Y220F

Associated Papers

Deep CRISPR mutagenesis characterizes the functional diversity of TP53 mutations.

Funk JS et al.

Nature Genetics, 2025

39774325 (PubMed )
Supplement: 41588_2024_2039_MOESM5_ESM.xlsx › SuppFig6

Sequence Neighborhoods Enable Reliable Prediction of Pathogenic Mutations in Cancer Genomes.

Banerjee S et al.

Cancers, 2021

34068918 (PubMed )
Supplement: cancers-13-02366-s001.zip › Supplementary_Tables_1202501.xlsx › Table_S7

Targeting Cavity-Creating p53 Cancer Mutations with Small-Molecule Stabilizers: the Y220X Paradigm.

Bauer MR et al.

Acs Chemical Biology, 2020

Oncogene-mediated regulation of p53 ISGylation and functions.

Huang YF et al.

Oncotarget, 2014

Therapeutic reactivation of mutant p53 protein by quinazoline derivatives.

Sutherland HS et al.

Investigational New Drugs, 2012

The ubiquitin-proteasome system is inhibited by p53 protein expression in human ovarian cancer cells.

Hwang IY et al.

Cancer Letters, 2010

Epidemiology of doublet/multiplet mutations in lung cancers: evidence that a subset arises by chronocoordinate events.

Chen Z et al.

Plos One, 2008

19005564 (PubMed )
Supplement: pone.0003714.s004.xls › Table_s-2
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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."