Associated Papers
Neoantigenic properties of TP53 variants influence cancer risk in individuals with Li-Fraumeni syndrome.
Montellier E et al.
Ebiomedicine, 2026
A quantitative, Bayesian-informed approach to gene-specific variant classification: Updated Expert Panel recommendations improve classification of TP53 germline variants for Li-Fraumeni syndrome.
Fortuno C et al.
Genome Medicine, 2025
Phosphorylation-driven regulation of SIRT1 in muscle senescence: Insights from molecular dynamics simulation and experimental validation.
Liu S et al.
International Journal of Biological Macromolecules, 2025
Clustering of TP53 variants into functional classes correlates with cancer risk and identifies different phenotypes of Li-Fraumeni syndrome.
Montellier E et al.
Iscience, 2024
Different impacts of TP53 mutations on cell cycle-related gene expression among cancer types.
Sasaki K et al.
Scientific Reports, 2023
Mutant p53 in cancer: from molecular mechanism to therapeutic modulation.
Chen X et al.
Cell Death & Disease, 2022
TP53_PROF: a machine learning model to predict impact of missense mutations in TP53.
Ben-Cohen G et al.
Briefings in Bioinformatics, 2022
ZNF498 promotes hepatocellular carcinogenesis by suppressing p53-mediated apoptosis and ferroptosis via the attenuation of p53 Ser46 phosphorylation.
Zhang X et al.
Journal of Experimental & Clinical Cancer Research : Cr, 2022
The HIF-1α/p53/miRNA-34a/Klotho axis in retinal pigment epithelial cells promotes subretinal fibrosis and exacerbates choroidal neovascularization.
Xie L et al.
Journal of Cellular and Molecular Medicine, 2021
Crotonylation at serine 46 impairs p53 activity.
Liao P et al.
Biochemical and Biophysical Research Communications, 2020
Cell Fate Regulation upon DNA Damage: p53 Serine 46 Kinases Pave the Cell Death Road.
Liebl MC et al.
Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology, 2019
Finding driver mutations in cancer: Elucidating the role of background mutational processes.
Brown AL et al.
Plos Computational Biology, 2019
Mutational processes shape the landscape of TP53 mutations in human cancer.
Giacomelli AO et al.
Nature Genetics, 2018
Role of p53 and transcription-independent p53-induced apoptosis in shear-stimulated megakaryocytic maturation, particle generation, and platelet biogenesis.
Luff SA et al.
Plos One, 2018
p53 Loses grip on PIK3CA expression leading to enhanced cell survival during platinum resistance.
Thakur B et al.
Molecular Oncology, 2016
An African-specific polymorphism in the TP53 gene impairs p53 tumor suppressor function in a mouse model.
Jennis M et al.
Genes & Development, 2016
Complex regulation of CREB-binding protein by homeodomain-interacting protein kinase 2.
Kovács KA et al.
Cellular Signalling, 2015
Pin1-Induced Proline Isomerization in Cytosolic p53 Mediates BAX Activation and Apoptosis.
Follis AV et al.
Molecular Cell, 2015
Che-1 modulates the decision between cell cycle arrest and apoptosis by its binding to p53.
Desantis A et al.
Cell Death & Disease, 2015
Mutant TP53 posttranslational modifications: challenges and opportunities.
Nguyen TA et al.
Human Mutation, 2014
Insights into wild-type and mutant p53 functions provided by genetically engineered mice.
Donehower LA
Human Mutation, 2014
Illuminating p53 function in cancer with genetically engineered mouse models.
Garcia PB et al.
Seminars in Cell & Developmental Biology, 2014
Drugging the p53 pathway: understanding the route to clinical efficacy.
Khoo KH et al.
Nature Reviews. Drug Discovery, 2014
A new p53 target gene, RKIP, is essential for DNA damage-induced cellular senescence and suppression of ERK activation.
Lee SJ et al.
Neoplasia (new York, N.y.), 2013
DNA-PK, ATM and ATR collaboratively regulate p53-RPA interaction to facilitate homologous recombination DNA repair.
Serrano MA et al.
Oncogene, 2013
The prolyl-isomerase Pin1 activates the mitochondrial death program of p53.
Sorrentino G et al.
Cell Death and Differentiation, 2013
p53 N-terminal phosphorylation: a defining layer of complex regulation.
Jenkins LM et al.
Carcinogenesis, 2012
Context-dependent enhancement of induced pluripotent stem cell reprogramming by silencing Puma.
Lake BB et al.
Stem Cells (dayton, Ohio), 2012
Phosphorylation of p53 modifies sensitivity to ionizing radiation.
Okaichi K et al.
Anticancer Research, 2011
Role of the SUMO-interacting motif in HIPK2 targeting to the PML nuclear bodies and regulation of p53.
Sung KS et al.
Experimental Cell Research, 2011
Understanding wild-type and mutant p53 activities in human cancer: new landmarks on the way to targeted therapies.
Goldstein I et al.
Cancer Gene Therapy, 2011
MYCN sensitizes human neuroblastoma to apoptosis by HIPK2 activation through a DNA damage response.
Petroni M et al.
Molecular Cancer Research : Mcr, 2011
p53 post-translational modification: deregulated in tumorigenesis.
Dai C et al.
Trends in Molecular Medicine, 2010
ATM augments nuclear stabilization of DYRK2 by inhibiting MDM2 in the apoptotic response to DNA damage.
Taira N et al.
The Journal of Biological Chemistry, 2010
Axin determines cell fate by controlling the p53 activation threshold after DNA damage.
Li Q et al.
Nature Cell Biology, 2009
Cooperativity dominates the genomic organization of p53-response elements: a mechanistic view.
Pan Y et al.
Plos Computational Biology, 2009
Monocytic leukemia zinc finger (MOZ) interacts with p53 to induce p21 expression and cell-cycle arrest.
Rokudai S et al.
The Journal of Biological Chemistry, 2009
Blocking of p53-Snail binding, promoted by oncogenic K-Ras, recovers p53 expression and function.
Lee SH et al.
Neoplasia (new York, N.y.), 2009
PP2A regulates ionizing radiation-induced apoptosis through Ser46 phosphorylation of p53.
Mi J et al.
Molecular Cancer Therapeutics, 2009
How important are post-translational modifications in p53 for selectivity in target-gene transcription and tumour suppression?
Olsson A et al.
Cell Death and Differentiation, 2007
DYRK2 is targeted to the nucleus and controls p53 via Ser46 phosphorylation in the apoptotic response to DNA damage.
Taira N et al.
Molecular Cell, 2007
Regulation of cyclin-dependent kinase 5 and p53 by ERK1/2 pathway in the DNA damage-induced neuronal death.
Lee JH et al.
Journal of Cellular Physiology, 2007
Ser46 phosphorylation regulates p53-dependent apoptosis and replicative senescence.
Feng L et al.
Cell Cycle (georgetown, Tex.), 2006
Protein kinase C delta regulates Ser46 phosphorylation of p53 tumor suppressor in the apoptotic response to DNA damage.
Yoshida K et al.
The Journal of Biological Chemistry, 2006
Defect in serine 46 phosphorylation of p53 contributes to acquisition of p53 resistance in oral squamous cell carcinoma cells.
Ichwan SJ et al.
Oncogene, 2006
Structural basis for gene activation by p53 family members.
Scoumanne A et al.
Cancer Biology & Therapy, 2005