Associated Papers
Neoantigenic properties of TP53 variants influence cancer risk in individuals with Li-Fraumeni syndrome.
Montellier E et al.
Ebiomedicine, 2026
A quantitative, Bayesian-informed approach to gene-specific variant classification: Updated Expert Panel recommendations improve classification of TP53 germline variants for Li-Fraumeni syndrome.
Fortuno C et al.
Genome Medicine, 2025
Clustering of TP53 variants into functional classes correlates with cancer risk and identifies different phenotypes of Li-Fraumeni syndrome.
Montellier E et al.
Iscience, 2024
Pharmacogenomic profiling of intra-tumor heterogeneity using a large organoid biobank of liver cancer.
Yang H et al.
Cancer Cell, 2024
Different impacts of TP53 mutations on cell cycle-related gene expression among cancer types.
Sasaki K et al.
Scientific Reports, 2023
TP53_PROF: a machine learning model to predict impact of missense mutations in TP53.
Ben-Cohen G et al.
Briefings in Bioinformatics, 2022
Novel Allosteric Mechanism of Dual p53/MDM2 and p53/MDM4 Inhibition by a Small Molecule.
Grinkevich VV et al.
Frontiers in Molecular Biosciences, 2022
Identification and monitoring of mutations in circulating cell-free tumor DNA in hepatocellular carcinoma treated with lenvatinib.
Fujii Y et al.
Journal of Experimental & Clinical Cancer Research : Cr, 2021
Mutation patterns in recurrent and/or metastatic oropharyngeal squamous cell carcinomas in relation to human papillomavirus status.
Reder H et al.
Cancer Medicine, 2021
Crotonylation at serine 46 impairs p53 activity.
Liao P et al.
Biochemical and Biophysical Research Communications, 2020
FBXW7 Confers Radiation Survival by Targeting p53 for Degradation.
Cui D et al.
Cell Reports, 2020
Incidence and distribution of UroSEEK gene panel in a multi-institutional cohort of bladder urothelial carcinoma.
Eich ML et al.
Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc, 2019
Abrogation of FBW7α-dependent p53 degradation enhances p53's function as a tumor suppressor.
Tripathi V et al.
The Journal of Biological Chemistry, 2019
Efficacy of liquid-based genetic diagnosis of endometrial cancer.
Matsuura M et al.
Cancer Science, 2018
Mutational processes shape the landscape of TP53 mutations in human cancer.
Giacomelli AO et al.
Nature Genetics, 2018
Molecular Scoring of Hepatocellular Carcinoma for Predicting Metastatic Recurrence and Requirements of Systemic Chemotherapy.
Nishida N et al.
Cancers, 2018
Distribution bias analysis of germline and somatic single-nucleotide variations that impact protein functional site and neighboring amino acids.
Pan Y et al.
Scientific Reports, 2017
Mutation spectrum of hepatocellular carcinoma from eastern-European patients betrays the impact of a complex exposome.
Tanase AM et al.
Journal of Exposure Science & Environmental Epidemiology, 2015
Exome sequencing of hepatocellular carcinomas identifies new mutational signatures and potential therapeutic targets.
Schulze K et al.
Nature Genetics, 2015
p53 Ser15 phosphorylation disrupts the p53-RPA70 complex and induces RPA70-mediated DNA repair in hypoxia.
Madan E et al.
The Biochemical Journal, 2012
Dyrk1A phosphorylates p53 and inhibits proliferation of embryonic neuronal cells.
Park J et al.
The Journal of Biological Chemistry, 2010
Regulation of cyclin-dependent kinase 5 and p53 by ERK1/2 pathway in the DNA damage-induced neuronal death.
Lee JH et al.
Journal of Cellular Physiology, 2007
Oncogenic Ras increases sensitivity of colon cancer cells to 5-FU-induced apoptosis.
Klampfer L et al.
Oncogene, 2005
Regulation of p53 stability and function in HCT116 colon cancer cells.
Kaeser MD et al.
The Journal of Biological Chemistry, 2004
Role of Pin1 in the regulation of p53 stability and p21 transactivation, and cell cycle checkpoints in response to DNA damage.
Wulf GM et al.
The Journal of Biological Chemistry, 2002
The prolyl isomerase Pin1 reveals a mechanism to control p53 functions after genotoxic insults.
Zacchi P et al.
Nature, 2002
Distinct sets of gene alterations in endometrial carcinoma implicate alternate modes of tumorigenesis.
Koul A et al.
Cancer, 2002
Regulation of the accumulation and function of p53 by phosphorylation of two residues within the domain that binds to Mdm2.
Bean LJ et al.
The Journal of Biological Chemistry, 2002
Increased p53 phosphorylation after microtubule disruption is mediated in a microtubule inhibitor- and cell-specific manner.
Stewart ZA et al.
Oncogene, 2001
DNA damage induced p53 stabilization: no indication for an involvement of p53 phosphorylation.
Blattner C et al.
Oncogene, 1999