Associated Papers
Neoantigenic properties of TP53 variants influence cancer risk in individuals with Li-Fraumeni syndrome.
Montellier E et al.
Ebiomedicine, 2026
A quantitative, Bayesian-informed approach to gene-specific variant classification: Updated Expert Panel recommendations improve classification of TP53 germline variants for Li-Fraumeni syndrome.
Fortuno C et al.
Genome Medicine, 2025
Clinical Significance of TP53-Mutant Clonal Hematopoiesis Across Diseases.
Usui Y et al.
Blood Cancer Discovery, 2025
TP53 minigene analysis of 161 sequence changes provides evidence for role of spatial constraint and regulatory elements on variant-induced splicing impact.
Canson DM et al.
Npj Genomic Medicine, 2025
Clustering of TP53 variants into functional classes correlates with cancer risk and identifies different phenotypes of Li-Fraumeni syndrome.
Montellier E et al.
Iscience, 2024
Scalable approaches for generating, validating and incorporating data from high-throughput functional assays to improve clinical variant classification.
Padigepati SR et al.
Human Genetics, 2024
Structural Adaptation of Secondary p53 Binding Sites on MDM2 and MDMX.
Higbee PS et al.
Journal of Molecular Biology, 2024
Different impacts of TP53 mutations on cell cycle-related gene expression among cancer types.
Sasaki K et al.
Scientific Reports, 2023
TP53_PROF: a machine learning model to predict impact of missense mutations in TP53.
Ben-Cohen G et al.
Briefings in Bioinformatics, 2022
Immune pathways and TP53 missense mutations are associated with longer survival in canine osteosarcoma.
Das S et al.
Communications Biology, 2021
Significant impact of circulating tumour DNA mutations on survival in metastatic breast cancer patients.
Muendlein A et al.
Scientific Reports, 2021
Mutational processes shape the landscape of TP53 mutations in human cancer.
Giacomelli AO et al.
Nature Genetics, 2018
In Situ Monitoring of p53 Protein and MDM2 Protein Interaction in Single Living Cells Using Single-Molecule Fluorescence Spectroscopy.
Du Z et al.
Analytical Chemistry, 2018
Conserved Helix-Flanking Prolines Modulate Intrinsically Disordered Protein:Target Affinity by Altering the Lifetime of the Bound Complex.
Crabtree MD et al.
Biochemistry, 2017
Structural basis of how stress-induced MDMX phosphorylation activates p53.
Chen X et al.
Oncogene, 2016
Disorder and residual helicity alter p53-Mdm2 binding affinity and signaling in cells.
Borcherds W et al.
Nature Chemical Biology, 2014
Molecular dynamic simulation insights into the normal state and restoration of p53 function.
Fu T et al.
International Journal of Molecular Sciences, 2012
C-terminal substitution of MDM2 interacting peptides modulates binding affinity by distinctive mechanisms.
Brown CJ et al.
Plos One, 2011
Systematic mutational analysis of peptide inhibition of the p53-MDM2/MDMX interactions.
Li C et al.
Journal of Molecular Biology, 2010
Molecular mechanism of the interaction between MDM2 and p53.
Schon O et al.
Journal of Molecular Biology, 2002