Varaico: Literature-Extracted Genetic Variants

Gene:TP53
Variant:p.E2fs
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TP53

NM_000546.6:p.E2fs

Associated Papers

Targeting Y220C mutated p53 by Foeniculum vulgare-derived phytochemicals as cancer therapeutics.

Garg S et al.

Journal of Molecular Modeling, 2023

Chaperones and Ubiquitin Ligases Balance Mutant p53 Protein Stability in Esophageal and Other Digestive Cancers.

Martinho MS et al.

Cellular and Molecular Gastroenterology and Hepatology, 2021

Evolutionary genomics of mammalian lung cancer genes reveals signatures of positive selection in APC, RB1 and TP53.

Emam M et al.

Genomics, 2020

Clinical cancer genomic profiling by three-platform sequencing of whole genome, whole exome and transcriptome.

Rusch M et al.

Nature Communications, 2018

30262806 (PubMed )
Supplement: 41467_2018_6485_MOESM9_ESM.xlsx › 6B.EXONIC_INDEL_VALIDATION

The Rb binding domain of HPV31 E7 is required to maintain high levels of DNA repair factors in infected cells.

Johnson BA et al.

Virology, 2017

E2F1 and E2F2 prevent replicative stress and subsequent p53-dependent organ involution.

Iglesias-Ara A et al.

Cell Death and Differentiation, 2015

Trans-splicing repair of mutant p53 suppresses the growth of hepatocellular carcinoma cells in vitro and in vivo.

He X et al.

Scientific Reports, 2015

25732051 (PubMed )
Supplement: srep08705-s1.pdf

The Mdm network and its regulation of p53 activities: a rheostat of cancer risk.

Eischen CM et al.

Human Mutation, 2014

Significance of human papillomavirus 16/18 infection in association with p53 mutation in lung carcinomas.

Yu Y et al.

The Clinical Respiratory Journal, 2013

Inhibition of Plk1 and Cyclin B1 expression results in panobinostat-induced G₂ delay and mitotic defects.

Prystowsky M et al.

Scientific Reports, 2013

A single nucleotide polymorphism in the Bax gene promoter affects transcription and influences retinal ganglion cell death.

Semaan SJ et al.

Asn Neuro, 2010

Survivin repression by p53, Rb and E2F2 in normal human melanocytes.

Raj D et al.

Carcinogenesis, 2008

Enterocyte proliferation and intestinal hyperplasia induced by simian virus 40 T antigen require a functional J domain.

Rathi AV et al.

Journal of Virology, 2007

TP53 alterations in relation to the cell cycle-associated proteins p21, cyclin D1, CDK4, RB, MDM2, and EGFR in cancers of the uterine corpus.

Skomedal H et al.

The Journal of Pathology, 1999

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."