Varaico: Literature-Extracted Genetic Variants

Gene:TP63
Variant:p.V143A
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TP63

NM_003722.5:p.V143A

Associated Papers

Disease-related p63 DBD mutations impair DNA binding by distinct mechanisms and varying degree.

Osterburg C et al.

Cell Death & Disease, 2023

Opposing Roles of Wild-type and Mutant p53 in the Process of Epithelial to Mesenchymal Transition.

Semenov O et al.

Frontiers in Molecular Biosciences, 2022

Regulation of p53 and Cancer Signaling by Heat Shock Protein 40/J-Domain Protein Family Members.

Kaida A et al.

International Journal of Molecular Sciences, 2021

Gain-of-Function Mutant p53: All the Roads Lead to Tumorigenesis.

Stein Y et al.

International Journal of Molecular Sciences, 2019

Different TP53 mutations are associated with specific chromosomal rearrangements, telomere length changes, and remodeling of the nuclear architecture of telomeres.

Samassekou O et al.

Genes, Chromosomes & Cancer, 2014

Rescuing the function of mutant p53.

Bullock AN et al.

Nature Reviews. Cancer, 2001

Transcriptional dysregulation of the p73L / p63 / p51 / p40 / KET gene in human squamous cell carcinomas: expression of Delta Np73L, a novel dominant-negative isoform, and loss of expression of the potential tumour suppressor p51.

Senoo M et al.

British Journal of Cancer, 2001

Mechanism of rescue of common p53 cancer mutations by second-site suppressor mutations.

Nikolova PV et al.

The Embo Journal, 2000

p53 compound heterozygosity in a severely affected child with Li-Fraumeni syndrome.

Quesnel S et al.

Oncogene, 1999

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."