Associated Papers
ABE9 fused to SpRY Cas9 nickase enables precise generation of bystander free mouse models.
Ong JK et al.
Scientific Reports, 2026
Lysosomal TPC2 channels disrupt Ca2+ entry and dopaminergic function in models of LRRK2-Parkinson's disease.
Gregori M et al.
The Journal of Cell Biology, 2025
Rab7a is an enhancer of TPC2 activity regulating melanoma progression through modulation of the GSK3β/β-Catenin/MITF-axis.
Abrahamian C et al.
Nature Communications, 2024
P-selectin-dependent leukocyte adhesion is governed by endolysosomal two-pore channel 2.
Goretzko J et al.
Cell Reports, 2023
Segregated cation flux by TPC2 biases Ca2+ signaling through lysosomes.
Yuan Y et al.
Nature Communications, 2022
Electrophysiology of Endolysosomal Two-Pore Channels: A Current Account.
Patel S et al.
Cells, 2022
Lsm12 is an NAADP receptor and a two-pore channel regulatory protein required for calcium mobilization from acidic organelles.
Zhang J et al.
Nature Communications, 2021
Agonist-mediated switching of ion selectivity in TPC2 differentially promotes lysosomal function.
Gerndt S et al.
Elife, 2020
Iron overload causes endolysosomal deficits modulated by NAADP-regulated 2-pore channels and RAB7A.
Fernández B et al.
Autophagy, 2016
Poring over two-pore channel pore mutants.
Penny CJ et al.
Messenger (los Angeles, Calif. : Print), 2015
Leucine-rich repeat kinase 2 regulates autophagy through a calcium-dependent pathway involving NAADP.
Gómez-Suaga P et al.
Human Molecular Genetics, 2012
An NAADP-gated two-pore channel targeted to the plasma membrane uncouples triggering from amplifying Ca2+ signals.
Brailoiu E et al.
The Journal of Biological Chemistry, 2010
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