Associated Papers
Cryo-EM Structure and Activator Screening of Human Tryptophan Hydroxylase 2.
Zhu K et al.
Frontiers in Pharmacology, 2022
In silico analysis of the tryptophan hydroxylase 2 (TPH2) protein variants related to psychiatric disorders.
Pereira GRC et al.
Plos One, 2020
The genomic landscape of malignant peripheral nerve sheath tumors: diverse drivers of Ras pathway activation.
Brohl AS et al.
Scientific Reports, 2017
Functional characterization of the neuron-restrictive silencer element in the human tryptophan hydroxylase 2 gene expression.
Nawa Y et al.
Journal of Neurochemistry, 2017
Genes in the serotonin pathway are associated with bipolar affective disorder in a Han Chinese population.
Xiang B et al.
Neuroscience Bulletin, 2014
Common obesity risk alleles in childhood attention-deficit/hyperactivity disorder.
Albayrak Ö et al.
American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics, 2013
Chronic SSRI treatment exacerbates serotonin deficiency in humanized Tph2 mutant mice.
Siesser WB et al.
Acs Chemical Neuroscience, 2013
Brain-specific tryptophan hydroxylase, TPH2, and 5-HTTLPR are associated with frontal lobe symptoms in Alzheimer's disease.
Engelborghs S et al.
Journal of Alzheimer's Disease : Jad, 2013
Tryptophan hydroxylase(2) gene polymorphisms predict brain serotonin synthesis in the orbitofrontal cortex in humans.
Booij L et al.
Molecular Psychiatry, 2012
Behavioral genetics of affective and anxiety disorders.
Domschke K et al.
Current Topics in Behavioral Neurosciences, 2012
Multigene interactions and the prediction of depression in the Wisconsin Longitudinal Study.
Roetker NS et al.
Bmj Open, 2012
A functional alternative splicing mutation in human tryptophan hydroxylase-2.
Zhang X et al.
Molecular Psychiatry, 2011
Association study of tryptophan hydroxylase 2 gene polymorphisms in bipolar disorder patients with panic disorder comorbidity.
Campos SB et al.
Psychiatric Genetics, 2011
Association analysis of the tryptophan hydroxylase 2 gene polymorphisms in patients with methamphetamine dependence/psychosis.
Kobayashi H et al.
Current Neuropharmacology, 2011
A population-specific HTR2B stop codon predisposes to severe impulsivity.
Bevilacqua L et al.
Nature, 2010
Targeting tryptophan hydroxylase 2 in affective disorder.
Popova NK et al.
Expert Opinion on Therapeutic Targets, 2010
Variations in tryptophan hydroxylase 2 linked to decreased serotonergic activity are associated with elevated risk for metabolic syndrome in depression.
Kloiber S et al.
Molecular Psychiatry, 2010
Distribution of the C1473G polymorphism in tryptophan hydroxylase 2 gene in laboratory and wild mice.
Osipova DV et al.
Genes, Brain, and Behavior, 2010
Alternative splicing and extensive RNA editing of human TPH2 transcripts.
Grohmann M et al.
Plos One, 2010
Population-specific functional variant of the TPH2 gene 2755C>A polymorphism contributes risk association to major depression and anxiety in Chinese peripartum women.
Lin YM et al.
Archives of Women's Mental Health, 2009
TPH2 is not a susceptibility gene for suicide in Japanese population.
Mouri K et al.
Progress in Neuro-psychopharmacology & Biological Psychiatry, 2009
Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment.
Gratacòs M et al.
American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics, 2009
Support for tryptophan hydroxylase-2 as a susceptibility gene for bipolar affective disorder.
Roche S et al.
Psychiatric Genetics, 2009
Functional properties of missense variants of human tryptophan hydroxylase 2.
McKinney JA et al.
Human Mutation, 2009
Investigation of the tryptophan hydroxylase 2 gene in bipolar I disorder in the Romanian population.
Grigoroiu-Serbanescu M et al.
Psychiatric Genetics, 2008
Rhesus monkey tryptophan hydroxylase-2 coding region haplotypes affect mRNA stability.
Chen GL et al.
Neuroscience, 2008
Mutations in human monoamine-related neurotransmitter pathway genes.
Haavik J et al.
Human Mutation, 2008
Common genetic variations in human brain-specific tryptophan hydroxylase-2 and response to antidepressant treatment.
Tzvetkov MV et al.
Pharmacogenetics and Genomics, 2008
Brain-specific tryptophan hydroxylase 2 (TPH2): a functional Pro206Ser substitution and variation in the 5'-region are associated with bipolar affective disorder.
Cichon S et al.
Human Molecular Genetics, 2008
Functional polymorphisms of the brain serotonin synthesizing enzyme tryptophan hydroxylase-2.
Zhang X et al.
Cellular and Molecular Life Sciences : Cmls, 2006
Response to Zhang et al. (2005): loss-of-function mutation in tryptophan hydroxylase-2 identified in unipolar major depression. Neuron 45, 11-16.
Zhou Z et al.
Neuron, 2005
Haplotype-based linkage of tryptophan hydroxylase 2 to suicide attempt, major depression, and cerebrospinal fluid 5-hydroxyindoleacetic acid in 4 populations.
Zhou Z et al.
Archives of General Psychiatry, 2005