Associated Papers
The C886T Mutation in the Th Gene Reduces the Activity of Tyrosine Hydroxylase in the Mouse Brain.
Alsalloum I et al.
Biochemistry. Biokhimiia, 2024
Cryo-EM Structure and Activator Screening of Human Tryptophan Hydroxylase 2.
Zhu K et al.
Frontiers in Pharmacology, 2022
In silico analysis of the tryptophan hydroxylase 2 (TPH2) protein variants related to psychiatric disorders.
Pereira GRC et al.
Plos One, 2020
Polymorphism of TPH2 Gene rs120074175 Is Not Associated with Risk Factors of Schizophrenia.
Laksono JP et al.
Journal of Pharmacy & Bioallied Sciences, 2019
Tryptophan hydroxylase 2 as a therapeutic target for psychiatric disorders: focus on animal models.
Kulikova EA et al.
Expert Opinion on Therapeutic Targets, 2019
Genetic variability in tryptophan hydroxylase 2 gene in alcohol dependence and alcohol-related psychopathological symptoms.
Plemenitaš A et al.
Neuroscience Letters, 2015
Serotonin deficiency alters susceptibility to the long-term consequences of adverse early life experience.
Sachs BD et al.
Psychoneuroendocrinology, 2015
Cerebral 5-HT2A receptor binding, but not mGluR2, is increased in tryptophan hydroxylase 2 decrease-of-function mice.
Jørgensen CV et al.
Neuroscience Letters, 2013
The effects of brain serotonin deficiency on behavioural disinhibition and anxiety-like behaviour following mild early life stress.
Sachs BD et al.
The International Journal of Neuropsychopharmacology, 2013
Tryptophan hydroxylase 2 (TPH 2) single nucleotide polymorphisms, suicide, and alcohol-related suicide.
Zupanc T et al.
Psychiatria Danubina, 2013
Associations Between Variations in TPH1 , TPH2 and SLC6A4 Genes and Postpartum Depression: A Study in the Jordanian Population.
Khabour O et al.
Balkan Journal of Medical Genetics : Bjmg, 2013
Cortical-amygdalar circuit dysfunction in a genetic mouse model of serotonin deficiency.
Dzirasa K et al.
The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 2013
Selective deletion of forebrain glycogen synthase kinase 3β reveals a central role in serotonin-sensitive anxiety and social behaviour.
Latapy C et al.
Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences, 2012
Tryptophan hydroxylase(2) gene polymorphisms predict brain serotonin synthesis in the orbitofrontal cortex in humans.
Booij L et al.
Molecular Psychiatry, 2012
TPH2 gene polymorphisms and major depression--a meta-analysis.
Gao J et al.
Plos One, 2012
A functional alternative splicing mutation in human tryptophan hydroxylase-2.
Zhang X et al.
Molecular Psychiatry, 2011
Tryptophan hydroxylase 2 gene is associated with major depressive disorder in a female Chinese population.
Shen X et al.
Journal of Affective Disorders, 2011
Influence of TPH2 variants on diagnosis and response to treatment in patients with major depression, bipolar disorder and schizophrenia.
Serretti A et al.
Psychiatry Research, 2011
TPH2 polymorphisms and alcohol-related suicide.
Zupanc T et al.
Neuroscience Letters, 2011
Polymorphism of the tryptophan hydroxylase 2 (TPH2) gene is associated with chimpanzee neuroticism.
Hong KW et al.
Plos One, 2011
Glycogen Synthase Kinase-3 is an Intermediate Modulator of Serotonin Neurotransmission.
Polter AM et al.
Frontiers in Molecular Neuroscience, 2011
No association between polymorphisms in four serotonin receptor genes, serotonin transporter gene and alcohol-related suicide.
Zupanc T et al.
Psychiatria Danubina, 2010
Targeting tryptophan hydroxylase 2 in affective disorder.
Popova NK et al.
Expert Opinion on Therapeutic Targets, 2010
Distribution of the C1473G polymorphism in tryptophan hydroxylase 2 gene in laboratory and wild mice.
Osipova DV et al.
Genes, Brain, and Behavior, 2010
Alternative splicing and extensive RNA editing of human TPH2 transcripts.
Grohmann M et al.
Plos One, 2010
Population-specific functional variant of the TPH2 gene 2755C>A polymorphism contributes risk association to major depression and anxiety in Chinese peripartum women.
Lin YM et al.
Archives of Women's Mental Health, 2009
TPH2 is not a susceptibility gene for suicide in Japanese population.
Mouri K et al.
Progress in Neuro-psychopharmacology & Biological Psychiatry, 2009
Tryptophan hydroxylase 2 gene is associated with major depression and antidepressant treatment response.
Tsai SJ et al.
Progress in Neuro-psychopharmacology & Biological Psychiatry, 2009
Functional properties of missense variants of human tryptophan hydroxylase 2.
McKinney JA et al.
Human Mutation, 2009
Resequencing of serotonin-related genes and association of tagging SNPs to citalopram response.
Peters EJ et al.
Pharmacogenetics and Genomics, 2009
Crystal structure of tryptophan hydroxylase with bound amino acid substrate.
Windahl MS et al.
Biochemistry, 2008
Investigation of the tryptophan hydroxylase 2 gene in bipolar I disorder in the Romanian population.
Grigoroiu-Serbanescu M et al.
Psychiatric Genetics, 2008
Rhesus monkey tryptophan hydroxylase-2 coding region haplotypes affect mRNA stability.
Chen GL et al.
Neuroscience, 2008
Mutations in human monoamine-related neurotransmitter pathway genes.
Haavik J et al.
Human Mutation, 2008
Genes regulating the serotonin metabolic pathway in the brain stem and their role in the etiopathogenesis of the sudden infant death syndrome.
Nonnis Marzano F et al.
Genomics, 2008
Common genetic variations in human brain-specific tryptophan hydroxylase-2 and response to antidepressant treatment.
Tzvetkov MV et al.
Pharmacogenetics and Genomics, 2008
Role of GSK3 beta in behavioral abnormalities induced by serotonin deficiency.
Beaulieu JM et al.
Proceedings of the National Academy of Sciences of the United States of America, 2008
Brain-specific tryptophan hydroxylase 2 (TPH2): a functional Pro206Ser substitution and variation in the 5'-region are associated with bipolar affective disorder.
Cichon S et al.
Human Molecular Genetics, 2008
Functional characterization of the human TPH2 5' regulatory region: untranslated region and polymorphisms modulate gene expression in vitro.
Chen GL et al.
Human Genetics, 2008
Absence of the Arg441His polymorphism in the tryptophan hydroxylase 2 gene in adults with anxiety disorders and depression.
Henningsson S et al.
American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics, 2007
Influence of human tryptophan hydroxylase 2 N- and C-terminus on enzymatic activity and oligomerization.
Tenner K et al.
Journal of Neurochemistry, 2007
Tryptophan hydroxylase-2 gene variation influences personality traits and disorders related to emotional dysregulation.
Gutknecht L et al.
The International Journal of Neuropsychopharmacology, 2007
Tryptophan hydroxylase 2 (TPH2) haplotypes predict levels of TPH2 mRNA expression in human pons.
Lim JE et al.
Molecular Psychiatry, 2007
Characterization of wild-type and mutant forms of human tryptophan hydroxylase 2.
Winge I et al.
Journal of Neurochemistry, 2007
A new gain-of-function allele in chimpanzee tryptophan hydroxylase 2 and the comparison of its enzyme activity with that in humans and rats.
Hong KW et al.
Neuroscience Letters, 2007
Polymorphisms in the neuronal isoform of tryptophan hydroxylase 2 are associated with bipolar disorder in French Canadian pedigrees.
Harvey M et al.
Psychiatric Genetics, 2007
Molecular genetics of bipolar disorder and depression.
Kato T
Psychiatry and Clinical Neurosciences, 2007
Tryptophan hydroxylase-2 gene polymorphisms in rhesus monkeys: association with hypothalamic-pituitary-adrenal axis function and in vitro gene expression.
Chen GL et al.
Molecular Psychiatry, 2006
Evidence that a DISC1 frame-shift deletion associated with psychosis in a single family may not be a pathogenic mutation.
Green EK et al.
Molecular Psychiatry, 2006
Genotyping of the G1463A (Arg441His) TPH2 polymorphism in a geriatric population of patients with major depression.
Bicalho MA et al.
Molecular Psychiatry, 2006